Anti-HSD3B1 antibody (ab65156)
Key features and details
- Rabbit polyclonal to HSD3B1
- Suitable for: ELISA
- Reacts with: Mouse
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-HSD3B1 antibody
See all HSD3B1 primary antibodies -
Description
Rabbit polyclonal to HSD3B1 -
Host species
Rabbit -
Tested applications
Suitable for: ELISAmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab65156 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ELISA |
Use at an assay dependent concentration.
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Notes |
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ELISA
Use at an assay dependent concentration. |
Target
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Function
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. -
Tissue specificity
Placenta and skin. Predominantly expressed in mammary gland tissue. -
Pathway
Lipid metabolism; steroid biosynthesis. -
Sequence similarities
Belongs to the 3-beta-HSD family. -
Cellular localization
Endoplasmic reticulum membrane. Mitochondrion membrane. - Information by UniProt
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Database links
- Entrez Gene: 15492 Mouse
- Entrez Gene: 15494 Mouse
- Entrez Gene: 29632 Rat
- Entrez Gene: 360348 Rat
- Entrez Gene: 682974 Rat
- SwissProt: O35469 Mouse
- SwissProt: P24815 Mouse
- SwissProt: P26149 Mouse
see all -
Alternative names
- 3 beta and steroid delta isomerase 1 antibody
- 3 beta and steroid hydroxy delta 5 steroid dehydrogenase antibody
- 3 beta HSD I antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (16)
ab65156 has been referenced in 16 publications.
- Ikeda Y et al. The conditional deletion of steroidogenic factor 1 (Nr5a1) in Sox9-Cre mice compromises testis differentiation. Sci Rep 11:4486 (2021). PubMed: 33627800
- Bai J et al. Discovery of methylpyrimidine ring-fused diterpenoid analogs as a novel testosterone synthesis promoter. RSC Adv 9:9709-9717 (2019). PubMed: 35520707
- Bai J et al. Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents. Eur J Med Chem 176:21-40 (2019). PubMed: 31091478
- Yang Q et al. Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function. Int J Endocrinol 2019:6785289 (2019). PubMed: 31263496
- Shi X & Fu L Piceatannol inhibits oxidative stress through modification of Nrf2-signaling pathway in testes and attenuates spermatogenesis and steroidogenesis in rats exposed to cadmium during adulthood. Drug Des Devel Ther 13:2811-2824 (2019). PubMed: 31496657