HSV1 + HSV2 gB antibody [T111] (ab8232)

Product Name 

HSV1 + HSV2 gB antibody [T111]

Product type 

Primary antibodies

Description 

Mouse monoclonal [T111] to HSV1 + HSV2 gB

Immunogen 

Extract of HSV-1 infected VERO (green monkey kidney) cells.

Specificity 

Recognizes gB antigen of both HSV type 1 and type 2.

Tested applications 
(see key)

ELISA, ICC/IF, IP

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
This antibody was proven to be suitable for detection of HSV in clinical samples.
For immunofluorescence the antibody binds to the surface of infected cells.

Cellular localization 

Virus envelope

Research areas 

Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Herpes simplex

Relevance 

There are two main types of Herpes Simplex Virus (HSV), 1 and 2. The primary difference between the two types is in where they typically establish latency in the body. HSV1 usually establishes latency in the trigeminal ganglion, a collection of nerve cells near the ear. From there, it tends to recur on the lower lip or face causing cold sores. HSV2 usually resides in the sacral ganglion at the base of the spine. From there, it recurs in the genital area but even this difference is not absolute as in rare cases it can infect any part of the body, including the eyes. Up to 30% of genital herpes are also caused by HSV1. Both HSV1 and 2 are highly contagious through contact.

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

T111

Isotype 

IgG2b

Purity 

Protein G purified

Storage buffer 

Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

Purified from ascites using protein A-affinity chromatography.

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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References for HSV1 + HSV2 gB antibody [T111] (ab8232)

  This product has been used in: (two most recent references)

Bystricka M et al. Monoclonal antibodies suitable for type-specific identification of herpes simplex viruses by a rapid culture assay. Acta Virol 43:399-402 (1999). PubMed: 10825932

Bystricka M et al. Monoclonal antibodies to the distinct antigenic sites on glycoproteins C and B and their protective abilities in herpes simplex virus infection. Acta Virol 41:5-12 (1997). PubMed: 9199708

See all 3 publication references for this product.


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