HSV1 + HSV2 gD antibody [2C10] (ab6507)

Product Name 

HSV1 + HSV2 gD antibody [2C10]

Product type 

Primary antibodies

Description 

Mouse monoclonal [2C10] to HSV1 + HSV2 gD

Immunogen 

Herpes Virus

Tested applications 
(see key)

ELISA, ICC, WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
ELISA: 1/102,400 (see reference for Sandwich ELISA).
ICC(IF): 1/3,200 (HSV-2) - 1/25,600 (HSV-1).
WB: 1/10,000.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Research areas 

Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Herpes simplex

Relevance 

Herpes simplex virus 1 and 2 (HSV-1 and HSV-2) are two species of the herpes virus family, Herpesviridae, which cause infections in humans.
They are also called Human Herpes Virus 1 and 2 (HHV-1 and HHV-2) and are neurotropic and neuroinvasive viruses; they enter and hide in the human nervous system, accounting for their durability in the human body. Under a microscope, HSV- 1 and 2 are virtually identical, sharing approximately 50% of their DNA. Both types infect the body's mucosal surfaces, usually the mouth or genitals, and then establish latency in the nervous system. HSV-1 is commonly associated with herpes outbreaks of the face known as cold sores or fever blisters, whereas HSV-2 is more often associated with genital herpes. Herpes simplex viruses (HSV) use multiple and sequential receptors to enter host cells. HSV glycoprotein D (gD) has been implicated in binding to cellular receptors that facilitate virus penetration into cells. Herpes simplex virus type 1 (HSV-1) glycoprotein D (gD) is an essential component of the entry apparatus that is responsible for viral penetration and subsequent cell-cell spread.

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

2C10

Myeloma 

NS1/1-Ag4-1

Isotype 

IgG2a

Light chain type 

kappa

Purity 

Protein A purified

Storage buffer 

Phosphate buffered saline

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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References for HSV1 + HSV2 gD antibody [2C10] (ab6507)

  This product has been used in: (two most recent references)

O'Donnell CD & Shukla D A novel function of heparan sulfate in the regulation of cell-cell fusion. J Biol Chem 284:29654-65 (2009). PubMed: 19726670

Tengvall S et al. CpG oligodeoxynucleotide augments HSV-2 glycoprotein D DNA vaccine efficacy to generate T helper 1 response and subsequent protection against primary genital herpes infection in mice. J Reprod Immunol 68:53-69 (2005). PubMed: 16229896
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