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Products:Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Herpes simplex
Overview
Product name
Anti-HSV1 ICP8 Major DNA binding protein antibody [11E2]
See all HSV1 ICP8 Major DNA binding protein products (2) ...
Description
Mouse monoclonal [11E2] to HSV1 ICP8 Major DNA binding protein
Tested applications
IP, WB, ICC/IFmore details
Cross reactivity
Reacts with HSV1. Not yet tested in other species.
Immunogen
Full length native protein (purified from U-35-VERO cells) (HSV).
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
11E2
Isotype
IgG1
Research areas
Microbiology >> Organism >> Virus >> DNA Virus >> double stranded DNA Virus >> Herpes simplex
Applications
Show applications key
Our Abpromise guarantee covers the use of ab20194 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP
WB
ICC/IF
Application notes
ICC/IF: Use at an assay dependent dilution (PMID 18434395).
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 129 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
Herpes simplex type 1 (HSV-1) belongs to a family that includes HSV-2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSV-1 and HSV-2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell. ICP8 is the major DNA binding protein of herpes simplex virus type 1.
Alternative names
- DBP antibody
- Herpes simplex virus type 1 DBP antibody
- HSV1 DBP antibody
see all
References for Anti-HSV1 ICP8 Major DNA binding protein antibody [11E2] (ab20194)
This product has been referenced in:
- Peng Het al. Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components. Proc Natl Acad Sci U S A 107:2461-6 (2010). ICC/IF.Read more (PubMed: 20133788) »
- Mohni KNet al. ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled. J Virol 84:12152-64 (2010). WB, ICC/IF.Read more (PubMed: 20861269) »
See all 6 publications for this product
Publishing research using ab20194? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"