Anti-Haptoglobin antibody [26E11] (ab133764)

Overview

• Product nameAnti-Haptoglobin antibody [26E11]See all Haptoglobin primary antibodies ...
• Description
  Mouse monoclonal [26E11] to Haptoglobin
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Haptoglobin purified from Human plasma.

• Positive controlHuman liver tissue

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: 0.03% Sodium azide
  Constituents: HEPES, 50% Glycerol, 0.88% Sodium chloride, 0.01% BSA
• Concentration information loading...
• PurityAmmonium Sulphate Precipitation
• Clonality Monoclonal
• Clone number26E11
• IsotypeIgG1
• Light chain typekappa
• Research Areas
  • Cardiovascular
  • Blood
  • Blood Cell Antigens
  • RBC Antigens

  • Cardiovascular
  • Blood
  • Serum Proteins

Applications

Target

• FunctionAs a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
  Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.
• Tissue specificityExpressed by the liver and secreted in plasma.
• Involvement in diseaseAnhaptoglobinemia (AHP) [MIM:614081]: A condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Congenital haptoglobin deficiency is a risk factor for anaphylactic non-hemolytic transfusion reactions. Note=The disease is caused by mutations affecting the gene represented in this entry.
• Sequence similaritiesBelongs to the peptidase S1 family.
  Contains 1 peptidase S1 domain.
  Contains 2 Sushi (CCP/SCR) domains.
• Cellular localizationSecreted.

Target information above from: UniProt accession P00738 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3240 Human
  • Omim: 140100 Human
  • SwissProt: P00738 Human
  • Unigene: 513711 Human
  • Unigene: 702099 Human

• Alternative names
  Binding peptide antibodyBP antibodyHaptoglobin alpha chain antibody

  Haptoglobin alpha(1S) beta antibodyHaptoglobin alpha(2FS) beta antibodyHaptoglobin beta chain antibodyHaptoglobin, alpha polypeptide antibodyHaptoglobin, beta polypeptide antibodyHP antibodyHP2 ALPHA2 antibodyHP2ALPHA2 antibodyHPA1S antibodyHPT antibodyHPT_HUMAN antibodyMGC111141 antibodyZonulin antibody

  see all

Anti-Haptoglobin antibody [26E11] images

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Haptoglobin antibody [26E11] (ab133764)
  Immunohistochemical analysis of formalin-fixed, paraffin embedded Human liver tissue labelling Haptoglobin with ab133764 at a 1/200 dilution followed by biotinylated horse anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen