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Product name
Harmine
Description
Potent and selective inhibitor of DYRK1A
Biological description
Potent and selective inhibitor of DYRK1A (dual specificity tyrosine-phosphorylated and -regulated kinase). (IC50 values are 0.08, 0.9, 0.8, 4.3 and 1.5 µM for DYRK1A, DYRK2, DYRK3, PIM3 and CK1 respectively). 5-HT antagonist and MAO inhibitor. Regulator of PPARγ expression and antidiabetic.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Country restrictions and/or license requirements may apply. Please contact customer services for further details.
Properties
Chemical name
7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole
Molecular Weight
212.25
Chemical structure
Molecular formula
C13H12N2O
CAS Number
442-51-3
Solubility
Soluble in DMSO to 100 mM
Storage instructions
Store at room temperature.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Kinase >> DYRK1A >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Harmine (ab120225)
This product has been referenced in:
- Waki H et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression. Cell Metab 5:357-70 (2007).Read more (PubMed: 17488638) »
- Bain J et al. The selectivity of protein kinase inhibitors: a further update. Biochem J 408:297-315 (2007).Read more (PubMed: 17850214) »
See all 3 publications for this product
Publishing research using ab120225? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"