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Hepatitis C Virus Core 1b protein (Beta-Galactosidase) (ab67745)

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Overview

  • Product nameHepatitis C Virus Core 1b protein (Beta-Galactosidase)See all Hepatitis C Virus Core 1b proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 2-192 of Hepatitis C Virus, serotype 1b, nucleocapsid core, immunodominant region. The protein is fused with b-galactosidase (114 kDa) at the N-terminus.
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesThis protein was purified by proprietary chromatographic techniques.
  • Biological activityThis protein is immunoreactive with sera of HCV-infected individuals.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8.0
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab67745 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution.
    ELISA ELISA: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        Capsid protein CCore protein p19Core protein p21Hepatitis C virus core protein
  • RelevanceHCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression. There are over 20 different subtypes of Hepatitis C Virus; HCV type 1b is mostly found in Europe and Asia. The prevalence of HCV type 1b infection has recently decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b are independent predictors for poor response to interferon-alpha therapy. HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.

    • References for Hepatitis C Virus Core 1b protein (Beta-Galactosidase) (ab67745)

    ab67745 has not yet been referenced specifically in any publications.

    Publishing research using ab67745 ? Please let us know so that we can cite the reference in this datasheet

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    In the WEB of your company, I found HCV core 1b protein (beta-Galactosidase) (ab67745). Is it certified free of lopopolysaccharide? I am going to use HCV core protein 1b to B and T lymphocytes to detect the change of IL-6, TNF, etc. What is the suitable p...

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    Thank you for your enquiry. Unfortunately, we have not tested the LPS (lipopolysaccharide) levels for this product to date, so it might contain a bit since we do use pyrogen free water for the purification. Regarding suitable products, I am afraid...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"