Overview
Product nameHepatitis C Virus Core 1b proteinSee all Hepatitis C Virus Core 1b proteins and peptides ...
Protein descriptionRecombinant fragment, corresponding to amino acids 2-119 of Hepatitis C Virus Core 1b containing the core nucleocapsid immunodominant regions; MWt 13 kDa.
Expression hostE. coli
Properties
Purity> 95
% by SDS-PAGE
Purification notesab91301 is purified by proprietary chromatographic techniques. Purity is >95% by SDS-PAGE and RP-HPLC
Biological activityab91301 is immunoreactive with sera of Hepatitis C Virus-infected individuals.
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: None
Constituents: 50% Glycerol, 0.25% Sarkosyl, 60mM Sodium chloride, 50mM Tris HCl, 10mM Glutathione, pH 8.0
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab91301
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|
Application
|
Notes |
| SDS-PAGE |
SDS-PAGE: Use at an assay dependent dilution. |
| WB |
WB: Use at an assay dependent dilution. |
| ELISA |
ELISA: Use at an assay dependent dilution. |
Protein info
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Alternative names
Capsid protein CCore protein p19Core protein p21Hepatitis C virus core protein
RelevanceHCV (Hepatitis C Virus) viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The hepatitis C virus (HCV) core protein represents the first 177 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. The N terminus of the core protein is involved in transcriptional repression.
There are over 20 different subtypes of Hepatitis C Virus; HCV type 1b is mostly found in Europe and Asia. The prevalence of HCV type 1b infection has recently decreased, although it still accounts for most HCV-related cirrhosis and hepatocellular carcinoma. High HCV viremia levels and HCV genotype type 1b are independent predictors for poor response to interferon-alpha therapy.
HCV core protein is among the most conserved proteins in HCV and is known to induce sensitization of cytotoxic T lymphocytes (CTL). Therefore, it is a prime candidate for a component of a potential HCV vaccine.
References for Hepatitis C Virus Core 1b protein (ab91301)
ab91301
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
