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Anti-Hepatitis C Virus Core Antigen antibody (ab58713)

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Overview

  • Product nameAnti-Hepatitis C Virus Core Antigen antibodySee all Hepatitis C Virus Core Antigen primary antibodies ...
  • Description
    Rabbit polyclonal to Hepatitis C Virus Core Antigen
  • Tested applicationsWB, ELISA more details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Hepatitis C Virus
  • Immunogen

    Synthetic peptide corresponding to N-terminal residues of Hepatitis C virus core protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab58713 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 21 kDa. for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA ELISA: Use at an assay dependent dilution.

Target

  • RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localizationEndoplasmic reticulum
  • Database links
    • Alternative names
        Core protein p19 antibodyHCcAg antibodyHCV core antigen antibody
        HCV core protein antibodyHepatitis C Virus core protein antibody
      see all

    References for Anti-Hepatitis C Virus Core Antigen antibody (ab58713)

    ab58713 has not yet been referenced specifically in any publications.

    Publishing research using ab58713 ? Please let us know so that we can cite the reference in this datasheet

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