Product nameHepatitis C Virus Core Antigen protein (Biotin)See all Hepatitis C Virus Core Antigen proteins and peptides ...
Protein descriptionRecombinant fusion protein, corresponding to core protein p21 of Hepatitis C Virus Hepatitis C Virus Core Antigen, MW 22 kDa, beta-galactosidase (114 kDa) fused at the N-terminus.
Expression hostE. coli
% by SDS-PAGE
Biological activityReacts strongly with human HCV positive serum.
Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: None
Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8
Concentration information loading...
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
||ELISA: Use at an assay dependent dilution.
||SDS-PAGE: Use at an assay dependent dilution.
||WB: Use at an assay dependent dilution.
RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication.
Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Cellular localizationEndoplasmic reticulum
Core protein p19HCV core antigenHCV core proteinHepatitis C Virus core protein
References for Hepatitis C Virus Core Antigen protein (Biotin) (ab49020)
has not yet been referenced specifically in any publications.
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