Overview
Product nameHepatitis C Virus Core Antigen protein (Rhodamine) (Tagged)See all Hepatitis C Virus Core Antigen proteins and peptides ...
Protein descriptionRecombinant full length protein (22kDa), corresponding to amino acids 2-192 of Hepatitis C Virus Core Antigen, tagged at N-terminal (114kDa) and labeled with rhodamine.
Expression hostE. coli
ConjugationRhodamine
Properties
Purity> 95
% by SDS-PAGE
Biological activityIt reacts positively with Human HCV serum.
FormLiquid
Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferPreservative: None
Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8
Concentration information loading...
Research Areas
Applications
Our Abpromise guarantee covers the use of
ab58919
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|
Application
|
Notes |
| SDS-PAGE |
|
| Enzyme Immunoassay - Control |
|
Application notesEIA-Ctrl: Use at an assay dependent dilution.
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
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Alternative names
Core protein p19HCcAgHCV core antigen
HCV core proteinHepatitis C Virus core protein
see all
RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication.
Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
Cellular localizationEndoplasmic reticulum
References for Hepatitis C Virus Core Antigen protein (Rhodamine) (Tagged) (ab58919)
ab58919
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
