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Hepatitis C Virus Core Antigen protein (ab49015)

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Overview

  • Product nameHepatitis C Virus Core Antigen proteinSee all Hepatitis C Virus Core Antigen proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 2-119 of Hepatitis C Virus (immunodominant regions) with a 6x His-tag.
  • Expression hostE. coli

    • Properties

  • Purity> 90 % by SDS-PAGE
  • Purification notesPurified.
  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab49015 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB
    ELISA
    Flow Cyt
  • Application notesELISA: Use at an assay dependent dilution. (0.1 microgram per ELISA well)
    Flow Cyt: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        Core protein p19HCV core antigenHCV core proteinHepatitis C Virus core protein
  • RelevanceThe hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.
  • Cellular localizationEndoplasmic reticulum

    • References for Hepatitis C Virus Core Antigen protein (ab49015)

    ab49015 has not yet been referenced specifically in any publications.

    Publishing research using ab49015 ? Please let us know so that we can cite the reference in this datasheet

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    exact sequence for ab49015 ?



    La protéine ab4905 correspond à 6x His-tag + séquence acides aminés 2-119 de la référence http://www.uniprot.org/blast/?about=P26664[2-191], Core Protein p21 (STNPKPQKK NKRNTNRRPQ DVKFPGGGQI VGGVYLLPRR G...

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    I am performing a direct ELISA for the detection of HCV antigens (core and NS4). SO I would like to know whether Hepatitis C Virus NS4 antibody [1G7] (Biotin) (ab2591) recognizes either Hepatitis C Virus NS4 protein (ab49027) or Hepatitis C Virus NS4 p...

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    Thank you for your enquiry. The antibody ab2591 will detect ab49028 and the antibody ab2583 will detect ab49015 in ELISA. A standard protocol for direct ELISA can be found under the following link: http://www.abcam.com/index.html?pageconfig=resour...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"