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Products:Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> Hepatitis A/C/E/G
Overview
Product name
Anti-Hepatitis C Virus E2 antibody
See all Hepatitis C Virus E2 products (3) ...
Description
Rabbit polyclonal to Hepatitis C Virus E2
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Hepatitis C Virus
Immunogen
A synthetic peptide corresponding to N-terminal residues of Hepatitis C Virus E2
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Microbiology >> Organism >> Virus >> RNA Virus >> ssRNA positive strand virus >> Hepatitis A/C/E/G
Applications
Show applications key
Our Abpromise guarantee covers the use of ab54556 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/ml(for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)
ELISA: Use at an assay dependent dilution.
Target
Relevance
Hepatitis C E2 is a virus envelope glycoprotein which forms a heterodimer with the E1 protein. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs are professional antigen presenting cells, critical for host immunity by inducing specific immune responses against a broad variety of pathogens. They act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
Cellular localization
Viral envelope protein.
Alternative names
- E2 protein antibody
- Envelope glycoprotein E2 antibody
- gp68 antibody
see all
Database links
- Entrez Gene: 951475 Hepatitis C Virus
- SwissProt: P26664 Hepatitis C Virus
- SwissProt: P27958 Hepatitis C Virus
References for Anti-Hepatitis C Virus E2 antibody (ab54556)
ab54556 has not yet been referenced specifically in any publications.
Publishing research using ab54556? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"