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Hepatitis C Virus NS4 protein (Tagged) (ab49030)

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Overview

  • Product nameHepatitis C Virus NS4 protein (Tagged)See all Hepatitis C Virus NS4 proteins and peptides ...
  • Protein descriptionRecombinant fusion protein, corresponding to amino acids 1658-1863 of Hepatitis C Virus NS4 a+b with ß-galactosidase fused at the N- terminus Molecular weight: 19kDa
  • Expression hostE. coli
  • ConjugationBiotin

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Biological activityReacts strongly with human HCV positive serum
  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 8M Urea, 20mM Tris HCl, 10mM Beta mercaptoethanol, pH 8.0
  • Concentration information loading...
  • Research Areas

    • Protein info

    • Alternative names
        HCVHCV NS4Hepatitis C Virus nonstructural antigen 4
        Non structural protein 4ANon structural protein 4BNS4ANS4Bp27p8
      see all
  • RelevanceNS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
  • Cellular localizationEndoplasmic reticulum; multi-pass membrane protein.

    • References for Hepatitis C Virus NS4 protein (Tagged) (ab49030)

    ab49030 has not yet been referenced specifically in any publications.

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    What is the genotype for this protein?

    Thank you for your phone call yesterday. I have heard back from my contact at the lab, and the genotype is 1B. I hope this information is helpful. Please let me know if you have any further questions.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"