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Hepatitis C Virus NS4 protein (ab49027)

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Overview

  • Product nameHepatitis C Virus NS4 proteinSee all Hepatitis C Virus NS4 proteins and peptides ...
  • Protein descriptionRecombinant mosaic protein containing the HCV NS4 immunodominant regions (1691-1710aa, 1712-1733aa, 1921-1940aa), from 1,2,3.5 genotypes with a beta-galactosidase tag.
  • Expression hostE. coli

    • Properties

  • Purification notesPurified.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, 1.5M Urea, 25mM Tris HCl, 1mM EDTA
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab49027 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    ELISA ELISA: Use at an assay dependent dilution.
    WB WB: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        HCVHCV NS4Hepatitis C Virus nonstructural antigen 4
        Non structural protein 4ANon structural protein 4BNS4ANS4Bp27p8
      see all
  • RelevanceNS4 A/B are two of the seven nonstructural (NS) proteins making up the HCV polyprotein. The NS proteins recruit the viral genome into an RNA replication complex, which is associated with rearranged cytoplasmic membranes. NS4A acts as a cofactor with the NS3 serine protease and stabilizes its folding. The NS3-NS4A complex is essential for the activation of the latter and allows membrane anchorage of NS3. HCV is a positive, single-stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. HCV is responsible for a large proportion of worldwide chronic viral hepatitides. Most of these infections develop into chronic hepatitis, which often progresses to liver cirrhosis and hepatocellular carcinoma. At present, (unlike hepatitis A and B), there is no vaccine to prevent hepatitis C infection. The hepatitis C virus (HCV) nonstructural protein 4B (NS4B) is a relatively hydrophobic 27-kDa protein. The 4A protein has a molecular weight of 6 kDa.
  • Cellular localizationEndoplasmic reticulum; multi-pass membrane protein.

    • References for Hepatitis C Virus NS4 protein (ab49027)

    ab49027 has not yet been referenced specifically in any publications.

    Publishing research using ab49027 ? Please let us know so that we can cite the reference in this datasheet

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