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Products:Signal Transduction >> Metabolism >> Vitamins / Minerals
Overview
Product name
Anti-Hephaestin antibody - Carboxyterminal end
See all Hephaestin products (4) ...
Description
Rabbit polyclonal to Hephaestin - Carboxyterminal end
Tested applications
IHC-FoFr, ELISA, IHC-FrFl, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Recombinant Fragment
Predicted to work with
Human
Immunogen
Synthetic peptide corresponding to C terminal residues of human Hephaestin precursor
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
-
Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-Hephaestin antibody - Carboxyterminal end (ab56042)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56042 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-FoFr: Use at an assay dependent concentration.
ELISA: Use at an assay dependent dilution.
IHC-FrFl: Use at an assay dependent concentration.
WB: Use a concentration of 1.0 µg/mlPredicted molecular weight: 130 kDa.(for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)
Target
Function
May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
Tissue specificity
Detected in breast, colon, bone trabecular cells and fibroblasts.
Sequence similarities
Belongs to the multicopper oxidase family.
Contains 6 plastocyanin-like domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ9BQS7
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CPL antibody
- Heph antibody
- HEPH_HUMAN antibody
- Hephaestin antibody
Database links
- Entrez Gene: 9843 Human
- Entrez Gene: 15203 Mouse
- Entrez Gene: 117240 Rat
- Omim: 300167 Human
- SwissProt: Q9BQS7 Human
- SwissProt: Q9Z0Z4 Mouse
- SwissProt: Q920H8 Rat
- Unigene: 31720 Human
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Anti-Hephaestin antibody - Carboxyterminal end images:
Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-Hephaestin antibody - Carboxyterminal end (ab56042)
IHC-FoFr image of ab56042 staining of Hephaestin in mouse duodenum. Adult mouse was perfused with 4% PFA in 0.1M PBS and duodenal tissue was frozen sectioned. The sections were incubated with ab56042 (1:500) for one hour at 24°C, followed by Alexa Fluor 488 conjugated secondary antibody.
This image was taken from an abreview submitted by Ruma Raha-Chowdhury.
References for Anti-Hephaestin antibody - Carboxyterminal end (ab56042)
ab56042 has not yet been referenced specifically in any publications.
Publishing research using ab56042? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"