Herbimycin A (ab142310)
- Product nameHerbimycin A
- DescriptionCell-permeable Src tyrosine kinase inhibitor
- Biological descriptionCell-permeable Src tyrosine kinase inhibitor and ansamycin antibiotic. Binds to the SH domain and inhibits p60v-src and p210BCR-ABL activity. Specific IKKβ and angiogenesis inhibitor. Anti-bacterial, anti-inflammatory and antitumor effects. Active in vitro and in vivo.
- Purity> 98%
- Chemical name[(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl]carbamate
- Molecular Weight574.66
- Chemical structure
- Molecular formulaC30H42N2O9
- CAS Number70563-58-5
- PubChem identifier6436247
- Storage instructionsStore at -20°C (desiccating conditions).
- Solubility overviewSoluble in DMSO to 10 mM
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for Herbimycin A (ab142310)
This product has been referenced in:
- Ogino S et al. Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit. Mol Pharmacol 65:1344-51 (2004). Read more (PubMed: 15155828) »
- Fukazawa H et al. Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett 340:155-8 (1994). Read more (PubMed: 8131836) »
- Uehara Y et al. Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds. Biochem Biophys Res Commun 163:803-9 (1989). Read more (PubMed: 2783121) »