Cell-permeable Src tyrosine kinase inhibitor and ansamycin antibiotic. Binds to the SH domain and inhibits p60v-src and p210BCR-ABL activity. Specific IKKβ and angiogenesis inhibitor. Anti-bacterial, anti-inflammatory and antitumor effects. Active in vitro and in vivo.
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Ogino S et al. Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit. Mol Pharmacol65:1344-51 (2004).
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Fukazawa H et al. Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett340:155-8 (1994).
Read more (PubMed: 8131836) »
Uehara Y et al. Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds. Biochem Biophys Res Commun163:803-9 (1989).
Read more (PubMed: 2783121) »