Overview

  • Product name
    Herbimycin A
  • Description
    Cell-permeable Src tyrosine kinase inhibitor
  • Biological description
    Cell-permeable Src tyrosine kinase inhibitor and ansamycin antibiotic. Binds to the SH domain and inhibits p60v-src and p210BCR-ABL activity. Specific IKKβ and angiogenesis inhibitor. Anti-bacterial, anti-inflammatory and antitumor effects. Active in vitro and in vivo.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Ogino S  et al. Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit. Mol Pharmacol 65:1344-51 (2004). Read more (PubMed: 15155828) »
  • Fukazawa H  et al. Labeling of v-Src and BCR-ABL tyrosine kinases with [14C]herbimycin A and its use in the elucidation of the kinase inactivation mechanism. FEBS Lett 340:155-8 (1994). Read more (PubMed: 8131836) »
  • Uehara Y  et al. Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds. Biochem Biophys Res Commun 163:803-9 (1989). Read more (PubMed: 2783121) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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