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Products:Epigenetics and Nuclear Signaling >> Transcription >> Domain Families >> Developmental Families >> Other
Overview
Product name
Hex peptide
Protein description
Synthetic peptide derived from within residues 200 to the C-terminus of Human Hex.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab34222 - Hex antibody.
Protein length
271 amino acids
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
Concentration information loading...
Applications
Application notes
This peptide can be used with studies using ab34222.
Protein info
Function
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.
Tissue specificity
Liver and promyelocytic leukemia cell line HL60.
Sequence similarities
Contains 1 homeobox DNA-binding domain.
Developmental stage
Expressed during hematopoiesis.
Cellular localization
Nucleus.
Target information above from: UniProt accessionQ03014
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for Hex peptide (ab28465)
This product has been referenced in:
- Hsieh SYet al. Profiling the proteome dynamics during the cell cycle of human hepatoma cells. Proteomics 8:2872-84 (2008).Read more (PubMed: 18655025) »
See 1 publication for this product
Publishing research using ab28465? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"