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Products:Epigenetics and Nuclear Signaling >> Histones >> H3 >> Citrullated
Overview
Product name
Histone H3 peptide - citrulline R26
See all Histone H3 products (2) ...
Protein description
Synthetic peptide derived from within residues 1 - 100 of Human Histone H3. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab19847 .
Protein length
135 amino acids
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
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Research areas
Epigenetics and Nuclear Signaling >> Histones >> H3 >> Citrullated
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ELISA - Histone H3 (citrulline R26) antibody (ab19847)
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Applications
Application notes
This peptide can be used with studies using ab19847.
Protein info
Relevance
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fibre is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Methylation of arginine residues within histone H3 has been linked to active transcription. However, the mechanism of demethylation of histones has remained elusive. Recently a process termed deimination has been described that converts histone arginine to citrulline and antagonizes arginine methylation (Cuthbert et al., 2004).
Cellular localization
Nuclear
Histone H3 peptide - citrulline R26 images:
ELISA - Histone H3 (citrulline R26) antibody (ab19847)
ab19847 gave a positive result in ELISA against the immunising peptide (ab20631) and a negative result using the non-modified equivalent peptide (ab2623). This indicates that ab19847 is specifically recognising Histone H3 citrulline R26.
Green and Orange lines: ELISA against immunising peptide (ab20631)
Red and Mauve lines: ELISA against non-modified peptide (ab2623)
References for Histone H3 peptide - citrulline R26 (ab20631)
ab20631 has not yet been referenced specifically in any publications.
Publishing research using ab20631? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"