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ELISA - Histone H3 (citrulline R26) antibody (ab19847)
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Product Name
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Histone H3 peptide - citrulline R26
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Product type
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Proteins and Peptides
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Peptide
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Synthetic peptide derived from within residues 1 - 100 of Human Histone H3.
This peptide was used as an immunogen for ab19847 .
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Research areas
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Chromatin and Nuclear Signaling >> Histones >> H3 >> Citrullated
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Relevance
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fibre is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
Methylation of arginine residues within histone H3 has been linked to active transcription. However, the mechanism of demethylation of histones has remained elusive. Recently a process termed deimination has been described that converts histone arginine to citrulline and antagonizes arginine methylation (Cuthbert et al., 2004).
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Storage buffer
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Preservative: None
Constituents: 0.001% Tween 20, HEPES, 2mM EDTA, 150mM Sodium chloride
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Histone H3 peptide - citrulline R26 is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for Histone H3 peptide - citrulline R26 images, references, products related to ab20631 and other tools.
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Histone H3 peptide - citrulline R26 images:
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 ELISA - Histone H3 (citrulline R26) antibody (ab19847)
ab19847 gave a positive result in ELISA against the immunising peptide (ab20631) and a negative result using the non-modified equivalent peptide (ab2623). This indicates that ab19847 is specifically recognising Histone H3 citrulline R26.
Green and Orange lines: ELISA against immunising peptide (ab20631)
Red and Mauve lines: ELISA against non-modified peptide (ab2623)
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Search PubMed (MEDLINE) for references to Histone H3
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