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HsGAD1 ChIP primer (Reverse) (ab83615)

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    Overview

    Product name

    HsGAD1 ChIP primer (Reverse)
    See all GAD1 products (3) ...

    Tested applications

    Real Time PCRmore details

    Properties

    Form

    Liquid

    Storage instructions

    Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

    Storage buffer

    Constituents: ddH20

    Purity

    Whole antiserum

    Research areas


    Immunology >> Immune System Diseases >> Autoimmune
    Signal Transduction >> Metabolism >> Amino Acids
    Neuroscience >> Neurotransmitter >> Amino Acids >> GABA

    Function

    Catalyzes the production of GABA.

    Tissue specificity

    Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain.

    Involvement in disease

    Defects in GAD1 are the cause of cerebral palsy spastic quadriplegic type 1 (CPSQ1) [MIM:603513]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest symmetrical, non-progressive spasticity and no adverse perinatal history or obvious underlying alternative diagnosis. Developmental delay, mental retardation and sometimes epilepsy can be part of the clinical picture.

    Sequence similarities

    Belongs to the group II decarboxylase family.

    Target information above from: UniProt accessionQ99259 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010).

    Information by UniProt

    Alternative names

    • 67 kDa glutamic acid decarboxylase
    • CPSQ1
    • DCE1_HUMAN
    • FLJ45882
    • GAD
    • GAD 1
    • GAD 67
    • GAD-67
    • GAD1
    • GAD67
    • glutamate decarboxylase 1
    • Glutamate decarboxylase 1 (brain, 67kDa)
    • Glutamate decarboxylase 1 brain 67kD
    • Glutamate decarboxylase 1 brain 67kDa
    • Glutamate decarboxylase 67 kDa isoform
    • OTTHUMP00000041054
    • OTTHUMP00000041055
    • OTTHUMP00000228572
    • SCP
    see all

    Applications

    Show applications key

    Our Abpromise guarantee covers the use of ab83615 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • ShowHide

      Real Time PCR

        See more...Read more →

      Real Time PCR: Use at an assay dependent dilution. (Suitable for the analysis of chromatin immunoprecipitated DNA using Taqman® real time PCR. Quantity provided for 200 reactions. Please see the protocol page for the instructions for this product.)

    Protocols

  • Instructions for RT-PCR of ChIP DNA (TaqMan)

    • References for HsGAD1 ChIP primer (Reverse) (ab83615)

    ab83615 has not yet been referenced specifically in any publications.

    Publishing research using ab83615? Please let us know so that we can cite the reference in this datasheet

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"