Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
Belongs to the heat shock protein 70 family.
The N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.
Phosphorylated upon DNA damage, probably by ATM or ATR. ISGylated.
Cytoplasm. Melanosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Rengarajan C et al. Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling. PLoS One9:e86373 (2014).
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Vickers TA & Crooke ST Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms. PLoS One9:e108625 (2014).
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