Anti-Hsc70 antibody (ab79857)
- Product nameAnti-Hsc70 antibodySee all Hsc70 primary antibodies ...
- DescriptionRabbit polyclonal to Hsc70
- SpecificityDoes not bind to Hsp70
- Tested applicationsWB more details
- Species reactivityReacts with: Fish
Predicted to work with: Mouse, Rat, Cow, Human, Zebrafish
Synthetic peptide specific to the Hsc70 of salmonid fish, conjugated to KLH
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
Constituents: Whole serum
- PurityWhole antiserum
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab79857 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/5000 - 1/50000. Predicted molecular weight: 71 kDa.|
- FunctionActs as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
- Tissue specificityUbiquitous.
- Sequence similaritiesBelongs to the heat shock protein 70 family.
- DomainThe N-terminal 1-386 residues constitute the ATPase domain, while residues 387-646 form the peptide-binding domain.
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
- Cellular localizationCytoplasm. Melanosome. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- Entrez Gene: 281831 Cow
- Entrez Gene: 3312 Human
- Entrez Gene: 15481 Mouse
- Entrez Gene: 24468 Rat
- Entrez Gene: 573376 Zebrafish
- Omim: 600816 Human
- SwissProt: P19120 Cow
- SwissProt: P11142 Human
- SwissProt: P63017 Mouse
- SwissProt: P63018 Rat
- SwissProt: Q90473 Zebrafish
- Unigene: 180414 Human
- Unigene: 290774 Mouse
- Unigene: 336743 Mouse
- Unigene: 351377 Mouse
- Unigene: 412745 Mouse
- Unigene: 120392 Rat
- Unigene: 201298 Rat
- Unigene: 75087 Zebrafish
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Anti-Hsc70 antibody images
All lanes : Anti-Hsc70 antibody (ab79857) at 1/100 dilution
Lane 1 : Extract prepared from whole salmon
Lane 2 : Extract prepared from whole salmon
Lysates/proteins at 10 µg per lane.
HRP-conjugated goat anti rabbit IgG
Predicted band size : 71 kDa
References for Anti-Hsc70 antibody (ab79857)
ab79857 has not yet been referenced specifically in any publications.