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Htz1 peptide (ab17826)

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Overview

Product name

Htz1 peptide

Protein description

Synthetic peptide derived from within residues 1 - 100 of S. cerevisiae Htz1. (Note: the amino acid sequence is proprietary). 

Expression host

CHO

Properties

Purity

Immunogen affinity purified

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Information available upon request.

Concentration

Concentration information loading...

Research areas

Epigenetics and Nuclear Signaling >> Histones >> Variants

Protein info

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Sequence similarities

Belongs to the histone H2A family.

Post-translational
modifications

Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
Acetylated on Lys-5, Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.
Not phosphorylated.

Cellular localization

Nucleus. Chromosome.

Target information above from: UniProt accessionP0C0S5 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Htz1 peptide images:

  Western blot

Western blot

All lanes : Anti-H2AFZ antibody (ab4626) at 1/500 dilution

Lane 1 : S. cerevisiae lysate.
Lane 2 : S. cerevisiae lysate. with Htz1 peptide (ab17826) at 1 mg/ml

Secondary
Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP) (ab6721) at 1/5000 dilution

Performed under reducing conditions.

Predicted band size : 14 kDa
Observed band size : 18 kDa (why is the actual band size different from the predicted?)
Additional bands at : 105 kDa (possible cross reactivity),55 kDa (possible cross reactivity),60 kDa (possible cross reactivity).

References for Htz1 peptide (ab17826)

ab17826 has not yet been referenced specifically in any publications.

Publishing research using ab17826? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"