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Products:Immunology >> Immunoglobulins >> Light Chain >> Kappa
Overview
Product name
Anti-Human Ig light chain antibody [7A9]
See all Human Ig light chain products (5) ...
Description
Mouse monoclonal [7A9] to Human Ig light chain
Specificity
Human IgA, IgG and IgM.
Tested applications
Conjugationmore details
Cross reactivity
Reacts with
Human
Immunogen
Mixture of light chains of human immunoglobulin.
General notes
Concentration varies from lot to lot and can be provided on request.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Protein A purified
Purification notes
Purity tested by electrophoresis.
Clonality
Monoclonal
Clone number
7A9
Myeloma
Sp2/0
Isotype
IgG2a
Research areas
Immunology >> Immunoglobulins >> Light Chain >> Lambda
Immunology >> Immunoglobulins >> Light Chain >> Kappa
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1942 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Conjugation
Application notes
Conjugation: Use at an assay dependent dilution.
Specific antibody titer is 1/1000000 by indirect ELISA
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
There are only two types of light chain: kappa and lambda in mammals. Other types of light chains are found in lower vertebrates as the Ig-Light-Iota chain in Chondrichthyes and Teleostei. In each antibody, only one type is present and the two chains are identical. Each light chain has two successive domains: one constant and one variable domain. In humans 60% of light chains are kappa and 40% lambda,whereas in the mouse 95% of light chains are kappa. The amino acid sequences of lambda chains vary slightly at a few positions, allowing them to be classified into subtypes. The number of subtypes varies between species. Monoclonal immunoglobulin free light chains (FLC) are found in the serum and urine (Bence-Jones protein) of patients with a number of B-cell proliferative disorders, including multiple myeloma. Changes in serum FLC concentrations can provide a rapid and sensitive indication of response to treatment.
Cellular localization
Cell Membrane: single-pass type I membrane protein and Secreted
Alternative names
- MGC111575 antibody
- HCAK1 antibody
- Ig kappa chain antibody
see all
Database links
- Entrez Gene: 3514 Human
- Omim: 147200 Human
- SwissProt: P01834 Human
- SwissProt: Q502W4 Human
- SwissProt: Q569I9 Human
- SwissProt: Q6GMV9 Human
- SwissProt: Q6GMW1 Human
- SwissProt: Q6GMX8 Human
see all
References for Anti-Human Ig light chain antibody [7A9] (ab1942)
ab1942 has not yet been referenced specifically in any publications.
Publishing research using ab1942? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"