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Product Name
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Human Ig light chain antibody [7A9]
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See all Human Ig light chain antibodies (4)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [7A9] to Human Ig light chain
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Immunogen
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Mixture of light chains of human immunoglobulin.
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Reacts with
(species key)
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Hu
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Specificity
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Human IgA, IgG and IgM.
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Tested applications
(see key)
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Conjugation
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Conjugation: Use at an assay dependent dilution.
Specific antibody titer is 1/1000000 by indirect ELISA
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane: single-pass type I membrane protein and Secreted
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Research areas
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Immunology >> Immunoglobulins >> Light Chain >> Lambda
Immunology >> Immunoglobulins >> Light Chain >> Kappa
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Relevance
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There are only two types of light chain: kappa and lambda in mammals. Other types of light chains are found in lower vertebrates as the Ig-Light-Iota chain in Chondrichthyes and Teleostei. In each antibody, only one type is present and the two chains are identical. Each light chain has two successive domains: one constant and one variable domain.
In humans 60% of light chains are kappa and 40% lambda,whereas in the mouse 95% of light chains are kappa. The amino acid sequences of lambda chains vary slightly at a few positions, allowing them to be classified into subtypes. The number of subtypes varies between species.
Monoclonal immunoglobulin free light chains (FLC) are found in the serum and urine (Bence-Jones protein) of patients with a number of B-cell proliferative disorders, including multiple myeloma. Changes in serum FLC concentrations can provide a rapid and sensitive indication of response to treatment.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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7A9
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Myeloma
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Sp2/0
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Isotype
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IgG2a
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Purity
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Protein A purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Purity tested by electrophoresis.
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Form
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Liquid
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Concentration
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2.000 mg/ml
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Storage instructions
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Store at +4°C.
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Notes
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Concentration varies from lot to lot and can be provided on request.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Human Ig light chain antibody [7A9] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to Human Ig light chain
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