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Anti-Human placental lactogen (epitope 2) antibody [INN-hPL-37] (ab11396)

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    Overview

    Product name

    Anti-Human placental lactogen (epitope 2) antibody [INN-hPL-37]

    Description

    Mouse monoclonal [INN-hPL-37] to Human placental lactogen (epitope 2)

    Specificity

    Radioimmunological direct binding studies were performed with 125I-labelled. hPL, hGH, hPRL and increasing amounts of INN-hPL-37. In addition, competitive RIA with unlabelled hGH, hPRL and hPL were used for characterization. In competitive RIA cross reactivity with hGH and hPRL was below 1%. Direct binding demonstrated 39% reactivity with hGH but no cross reactivity with hPRL.

    Tested applications

    RIAmore details

    Cross reactivity

    Reacts with

    Human

    Immunogen

    Human placental lactogen.

    General notes

    This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

    Properties

    Form

    Liquid

    Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Storage buffer

    Preservative: 0.09% Sodium Azide.

    Concentration

    Concentration information loading...

    Purity

    Protein A purified

    Purification notes

    Purification by affinity chromatography.

    Clonality

    Monoclonal

    Clone number

    INN-hPL-37

    Myeloma

    x63-Ag8.653

    Isotype

    IgG1

    Research areas

    Signal Transduction >> Growth Factors/Hormones >> Hormones

    • Immunocytochemistry/ Immunofluorescence - Human placental lactogen (epitope 2) antibody [INN-hPL-37] (ab11396)Immunocytochemistry/ Immunofluorescence - Human placental lactogen (epitope 2) antibody [INN-hPL-37] (ab11396) image (enlarge)

    Applications

    Show applications key

    Our Abpromise guarantee covers the use of ab11396 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Target

    Relevance

    Placental lactogen is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites.

    Cellular localization

    Secreted

    Alternative names

    • choriomammotropin antibody
    • Chorionic somatomammotropin A antibody
    • chorionic somatomammotropin antibody
    • Chorionic somatomammotropin hormone 1 (placental lactogen) antibody
    • chorionic somatomammotropin hormone 1 antibody
    • Chorionic somatomammotropin hormone 2 antibody
    • CS 1 antibody
    • CS-2 antibody
    • CS-B antibody
    • CSA antibody
    • CSB antibody
    • CSH1 antibody
    • CSMT antibody
    • hCS A antibody
    • hCSB antibody
    • Lactogen precursor antibody
    • Lactogen, placental antibody
    • PL antibody
    • placental lactogen antibody
    see all

    Database links

    Anti-Human placental lactogen (epitope 2) antibody [INN-hPL-37] images:

      Immunocytochemistry/ Immunofluorescence - Human placental lactogen (epitope 2) antibody [INN-hPL-37] (ab11396)

    Immunocytochemistry/ Immunofluorescence - Human placental lactogen (epitope 2) antibody [INN-hPL-37] (ab11396)

    ab11396 at 1/100 staining human BeWo cells (placenta, choriocarcinoma) by ICC/IF. The cells were paraformaldehyde fixed and blocked with BSA prior to incubation with the antibody for 30 minutes. A FITC conjugated goat anti-mouse IgG antibody was used as the secondary antibody. The image is shown in the upper right hand panel. In this experiment ab15554 was used as a positive control (bottom left hand panel). Cells were counter stained with DAPI (upper left hand panel).

    This image is courtesy of an Abreview submitted by Dr Stoil Dmitrov

    See Abreview

    References for Anti-Human placental lactogen (epitope 2) antibody [INN-hPL-37] (ab11396)

    ab11396 has not yet been referenced specifically in any publications.

    Publishing research using ab11396? Please let us know so that we can cite the reference in this datasheet

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"