Hydrocortisone, Adrenal glucocorticoid (ab141250)
Key features and details
- Adrenal glucocorticoid; immunosuppressant
- CAS Number: 50-23-7
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Hydrocortisone, Adrenal glucocorticoid -
Description
Adrenal glucocorticoid; immunosuppressant -
Alternative names
- Cortisol
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Biological description
Adrenal glucocorticoid. Stimulates gluconeogenesis, activates anxiolytic and anti-inflammatory pathways.
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Purity
> 99% -
CAS Number
50-23-7 -
Chemical structure
Properties
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Chemical name
(11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione -
Molecular weight
362.47 -
Molecular formula
C21H30O5 -
PubChem identifier
108888 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OCC(=O)[C@@]4(O)CC[C@@H]2[C@]4(C)C[C@H](O)[C@@H]1[C@@]3(C)CCC(=O)C=C3CC[C@H]12 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (9)
ab141250 has been referenced in 9 publications.
- Zhang Y et al. MicroRNA-18 facilitates the stemness of gastric cancer by downregulating HMGB3 though targeting Meis2. Bioengineered 13:9959-9972 (2022). PubMed: 35416122
- Dai Y et al. ISG15 enhances glioma cell stemness by promoting Oct4 protein stability. Environ Toxicol 37:2133-2142 (2022). PubMed: 35506701
- Lu Y et al. EHD1 promotes the cancer stem cell (CSC)-like traits of glioma cells via interacting with CD44 and suppressing CD44 degradation. Environ Toxicol 37:2259-2268 (2022). PubMed: 35616188
- Hong Q et al. Long non-coding RNA TDRG1 aggravates colorectal cancer stemness by binding with miR-873-5p to upregulate PRKAR2. Environ Toxicol 37:2366-2374 (2022). PubMed: 35730470
- Ben Halima H et al. A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis. Micromachines (Basel) 13:N/A (2022). PubMed: 36557534
- Ben Halima H et al. A silicon nitride ISFET based immunosensor for tumor necrosis factor-alpha detection in saliva. A promising tool for heart failure monitoring. Anal Chim Acta 1161:338468 (2021). PubMed: 33896556
- Jiang P et al. New function of the CD44 gene: Lipid metabolism regulation in bovine mammary epithelial cells. J Dairy Sci 103:6661-6671 (2020). PubMed: 32359993
- Munje RD et al. A new paradigm in sweat based wearable diagnostics biosensors using Room Temperature Ionic Liquids (RTILs). Sci Rep 7:1950 (2017). PubMed: 28512341
- Munje RD et al. Flexible nanoporous tunable electrical double layer biosensors for sweat diagnostics. Sci Rep 5:14586 (2015). PubMed: 26420511