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Anti-ICAM1 antibody [YN1/1.7.4] (ab25375)

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Overview

Product name

Anti-ICAM1 antibody [YN1/1.7.4]
See all ICAM1 products (46) ...

Description

Rat monoclonal [YN1/1.7.4] to ICAM1

Tested applications

IP, IHC-Fr, Blocking, WBmore details

Cross reactivity

Reacts with

Mouse

Immunogen

The details of the immunogen for this antibody are not available.

Positive control

PMA or LPS stimulated T-cell line such as EL-4 or 18-81

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 100mM Borate buffered saline, pH 8.2

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

YN1/1.7.4

Isotype

IgG2b

Light chain type

kappa

Research areas

Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Cell adhesion molecules
Immunology >> Cell Type Markers >> CD >> Adhesion

Applications

Show applications key

Our Abpromise guarantee covers the use of ab25375 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

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    IP

     IP: Use at an assay depe...Read more →

    IP: Use at an assay dependent dilution. (PubMed: 2573511Use at an assay dependent dilution (see PubMed 2573511).)

  • ShowHide2 Images

    IHC-Fr

    Five stars (2 Abreviews) IHC-Fr: Use at an assay ...Read more →

    IHC-Fr: Use at an assay dependent dilution. (PubMed: 8943409Use at an assay dependent dilution (see PubMed 8943409).)

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    Blocking

     BL: Use at an assay depe...Read more →

    BL: Use at an assay dependent dilution. (PubMed: 2981916Use at an assay dependent dilution (see PubMed 2981916).)

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    WB

     WB: Use at an assay depe...Read more →

    WB: Use at an assay dependent dilution. Detects a band of approximately 95 kDa (predicted molecular weight: 85-110 kDa).(PubMed: 8095510)

Target

Function

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.

Sequence similarities

Belongs to the immunoglobulin superfamily. ICAM family.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Post-translational
modifications

Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Cellular localization

Membrane.

Target information above from: UniProt accessionP05362 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • BB 2 antibody
  • BB2 antibody
  • CD 54 antibody
  • CD54 antibody
  • CD54 antigen antibody
  • Cell surface glycoprotein P3.58 antibody
  • Human rhinovirus receptor antibody
  • ICAM 1 antibody
  • ICAM-1 antibody
  • ICAM1 antibody
  • ICAM1_HUMAN antibody
  • Intercellular adhesion molecule 1 antibody
  • Major group rhinovirus receptor antibody
  • MALA 2 antibody
  • MALA2 antibody
  • MyD 10 antibody
  • MyD10 antibody
  • P3.58 antibody
  • Surface antigen of activated B cells antibody
see all

Database links

References for Anti-ICAM1 antibody [YN1/1.7.4] (ab25375)

This product has been referenced in:

  • Rudolph TKet al. Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 30:938-45 (2010). IHC-Fr; Mouse.Read more (PubMed: 20167658) »
  • Moussa Oet al. Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res 68:4097-104 (2008). WB; Human.Read more (PubMed: 18519668) »

See all 6 publications for this product

Publishing research using ab25375? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"