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Products:Signal Transduction >> Protein Phosphorylation >> pSer / pThr
Overview
Product name
Anti-ICAM3 antibody [MEM-171]
See all ICAM3 products (12) ...
Description
Mouse monoclonal [MEM-171] to ICAM3
Tested applications
Flow Cyt, IPmore details
Cross reactivity
Reacts with
Human
Immunogen
Tissue / cell preparation (Human granulocytes).
Epitope
MEM 171 recognizes an epitope in the D2 domain of human CD50 (ICAM 3).
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
>95% by SDS-PAGE
Purification notes
Purified from ascites by protein A affinity chromatography.
Clonality
Monoclonal
Clone number
MEM-171
Isotype
IgG1
Research areas
Immunology >> Cell Type Markers >> CD >> Adhesion
Signal Transduction >> Adapters >> Transmembrane
Signal Transduction >> Protein Phosphorylation >> pSer / pThr
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1048 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use a concentration of 4 µg/ml
IP: Use at an assay dependent concentration.
Target
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.
Sequence similarities
Belongs to the immunoglobulin superfamily. ICAM family.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Post-translational
modifications
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains.
Cellular localization
Membrane.
Target information above from: UniProt accessionP32942
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD50 antibody
- CDW 50 antibody
- CDW50 antibody
see all
Database links
- Entrez Gene: 3385 Human
- Omim: 146631 Human
- SwissProt: P32942 Human
- Unigene: 353214 Human
- Unigene: 654563 Human
References for Anti-ICAM3 antibody [MEM-171] (ab1048)
This product has been referenced in:
- Kishimoto T. (Eds.) et al. Leucocyte typing VI. Garland Publishing Inc. : (1997).Read more (PubMed: ) »
See 1 publication for this product
Publishing research using ab1048? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"