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Products:Immunology >> Innate Immunity >> Macrophage / Inflamm.
Overview
Product name
Anti-ICEBERG antibody
Description
Rabbit polyclonal to ICEBERG
Specificity
This antibody reacts predominantly with ICEBERG.
Tested applications
WB, IP, ELISAmore details
Cross reactivity
Reacts with
Rat, Human
Immunogen
Synthetic peptide (Human).
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.02% sodium azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Apoptosis >> Intracellular >> Caspases etc >> Inhibitors
Immunology >> Innate Immunity >> Macrophage / Inflamm.
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3684 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
IP
ELISA
Application notes
Immunoprecipitation: use at a concentration of 3.0 - 5.0 µg / extract from 107 cells.
Western Blotting: use at a concentration of 0.5 - 2.0 µg/ml.
ELISA: use at a concentration of 0.1 - 1.0 µg/ml.
Not tested in other applications.
Optimal dilutions / concentrations should be determined by the end user.
By Western blot, this antibody detects a band of approximately 10 kDa rat brain lysate, which corresponds to the predicted molecular weight of ICEBERG.
Samples were boiled prior to subjecting to a15% SDS-polyacrylamide gel electrophoresis.
Target
Function
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
Tissue specificity
Primarily expressed in the heart and placenta.
Sequence similarities
Contains 1 CARD domain.
Target information above from: UniProt accessionP57730
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CAR18_HUMAN antibody
- CARD18 antibody
- Caspase 1 inhibitor Iceberg antibody
see all
Database links
- Entrez Gene: 59082 Human
- Omim: 605354 Human
- SwissProt: P57730 Human
- Unigene: 56279 Human
References for Anti-ICEBERG antibody (ab3684)
ab3684 has not yet been referenced specifically in any publications.
Publishing research using ab3684? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"