Anti-IDH3B antibody (ab112544)

Overview

• Product nameAnti-IDH3B antibodySee all IDH3B primary antibodies ...
• Description
  Rabbit polyclonal to IDH3B
• Tested applicationsWB, ELISA, IHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat
• Immunogen

  Recombinant fragment, corresponding to amino acids 90-378 of Human IDH3B (BC001960).

• Positive controlHuman placenta, fetal heart and Jurkat cell lysates; Human fetal skeletal muscle tissue.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferpH: 7.20
  Preservative: 0.02% Sodium azide
  Constituents: 1% BSA, 98% PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Pathways and Processes
  • Mitochondrial Metabolism
  • Mitochondrial markers

  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Signal Transduction
  • Metabolism
  • Mitochondrial

Applications

Target

• Involvement in diseaseDefects in IDH3B are the cause of retinitis pigmentosa type 46 (RP46) [MIM:612572]. RP is a retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
• Sequence similaritiesBelongs to the isocitrate and isopropylmalate dehydrogenases family.
• Cellular localizationMitochondrion.

Target information above from: UniProt accession O43837 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3420 Human
  • Entrez Gene: 170718 Mouse
  • Entrez Gene: 94173 Rat
  • Omim: 604526 Human
  • SwissProt: O43837 Human
  • SwissProt: Q68FX0 Rat
  • SwissProt: Q68FX0 Rat
  • Unigene: 436405 Human

  • Unigene: 29590 Mouse
  • Unigene: 1093 Rat

  see all

• Alternative names
  FLJ11043 antibodyH-IDHB antibodyIDH3B antibody

  IDH3B_HUMAN antibodyIsocitrate dehydrogenase [NAD] subunit beta antibodyIsocitrate dehydrogenase [NAD] subunit beta, mitochondrial antibodyisocitrate dehydrogenase 3, beta subunit antibodyIsocitric dehydrogenase antibodyIsocitric dehydrogenase subunit beta antibodyMGC903 antibodymitochondrial antibodyNAD(+)-specific ICDH antibodyNAD(+)-specific ICDH subunit beta antibodyNAD+-specific isocitrate dehydrogenase b subunit antibodyNAD+-specific isocitrate dehydrogenase beta antibodyOTTHUMP00000030023 antibodyOTTHUMP00000030024 antibodyRP46 antibody

  see all

Anti-IDH3B antibody images

• 

  Western blot - IDH3B antibody (ab112544)
  All lanes : Anti-IDH3B antibody (ab112544) at 1/500 dilution
  
  Lane 1 : Human fetal heart lysate
  Lane 2 : Human placenta lysate
  Lane 3 : Jurkat cell lysate
  
  
  Predicted band size : 42 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - IDH3B antibody (ab112544)
  Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human fetal skeletal muscle tissue, using ab112544 at 1/100 dilution. Note cytoplasmic staining.