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Products:Immunology >> Innate Immunity >> Cytokines >> Interferons
Overview
Product name
Anti-IFITM1 antibody
See all IFITM1 products (4) ...
Description
Rabbit polyclonal to IFITM1
Specificity
ab70477 recognises all 3 isoforms of IFITMs (IFITM1, IFITM2 and IFITM3).
Tested applications
Cross reactivity
Reacts with
Human
Predicted to work with
Chimpanzee, Rhesus monkey
Immunogen
Synthetic peptide: HKEEHEVAVLGAPPSTILPRST, corresponding to N terminal amino acids 2-23 of Human IFITM1
HKEEHEVAVL GAPPSTILPR ST
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Tumor biomarkers >> Other
Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> p53 pathway
Stem Cells >> Signaling Pathways >> TGF beta >> Interferon gamma
Stem Cells >> Signaling Pathways >> Wnt >> Surface Molecules
Signal Transduction >> Adapters >> Transmembrane
Immunology >> Innate Immunity >> Cytokines >> Interferons
Applications
Show applications key
Our Abpromise guarantee covers the use of ab70477 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/2000Predicted molecular weight: 14 kDa.
Target
Function
IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activition or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
Sequence similarities
Belongs to the CD225 family.
Post-translational
modifications
Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity against influenza virus.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionP13164
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 9-27 antibody
- CD 225 antibody
- CD 225 antigen antibody
see all
Database links
- Entrez Gene: 8519 Human
- Omim: 604456 Human
- SwissProt: P13164 Human
- Unigene: 458414 Human
References for Anti-IFITM1 antibody (ab70477)
This product has been referenced in:
- Singh Ret al. Association of TRIM22 with Type 1 Interferon Response and Viral Control during Primary HIV-1 Infection. J Virol : (2010).Read more (PubMed: 20980524) »
See 1 publication for this product
Publishing research using ab70477? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"