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Anti-IFNAR2 antibody (ab51545)

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Overview

Product name

Anti-IFNAR2 antibody
See all IFNAR2 products (4) ...

Description

Chicken polyclonal to IFNAR2

Tested applications

WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Purified IFNAR2 intra cellular domain recombinant protein (15KD) (Human)

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

IgY fraction

Clonality

Polyclonal

Isotype

IgY

Research areas

Cancer >> Tumor immunology >> Cytokines >> Interferons
Epigenetics and Nuclear Signaling >> Nuclear Signaling Pathways >> STATs
Signal Transduction >> Signaling Pathway >> Nuclear Signaling >> STATs
Immunology >> Innate Immunity >> Cytokines >> Interferons

Applications

Show applications key

Our Abpromise guarantee covers the use of ab51545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

Application notes

WB: 1/500 - 1/5000. Predicted molecular weight: 58 kDa. This antibody was tested using a 15kDA human IFNAR2 recombinant fragment only.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.

Tissue specificity

Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

Sequence similarities

Belongs to the type II cytokine receptor family.

Post-translational
modifications

Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types.
Glycosylated.

Cellular localization

Secreted and Membrane.

Target information above from: UniProt accessionP48551 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • IFN alpha REC antibody
  • IFN-alpha binding protein antibody
  • IFN-alpha/beta receptor 2 antibody
  • IFN-R-2 antibody
  • IFNABR antibody
  • IFNAR2 antibody
  • IFNARB antibody
  • IFNR antibody
  • INAR2_HUMAN antibody
  • Interferon alpha binding protein antibody
  • Interferon alpha/beta receptor 2 antibody
  • Interferon alpha/beta receptor beta chain antibody
  • Type I interferon receptor 2 antibody
  • Type I interferon receptor antibody
see all

Database links

References for Anti-IFNAR2 antibody (ab51545)

This product has been referenced in:

See 1 publication for this product

Publishing research using ab51545? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"