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Overview

  • Product nameIGF1 protein (Active)See all IGF1 proteins and peptides ...
  • Protein descriptionRecombinant full length Rat IGF1: a single, non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 8 kDa. (Swiss-Prot P08025).
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesThis protein was purified by proprietary chromatographic techniques Purity: Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
  • FormLyophilised:Reconstitute in sterile 18MOhm/cm water at not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
  • Storage instructionsAliquot and store at -80°C. Avoid repeated freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Storage bufferPreservative: None
    No additives
  • Concentration information loading...
  • Additional notesFor long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab73459 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    Functional Studies
  • Application notesBiological Activity:
    The ED50 was calculated using 2 methods:
    1. Stimulation of protein synthesis in rat L6 myoblasts; ED50 was found to be < 30 ng/ml.
    2. Type 1 IGF receptor binding assay; ED50 was found to be <10 ng/ml.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Protein info

    • Alternative names
        IBP1IGF 1IGF I
        IGF IAIGF IBIGF-IIgf1IGF1_HUMANIGFIIGFIAInsulin like growth factor 1Insulin like growth factor 1 (somatomedin C)Insulin like growth factor IAInsulin like growth factor IBInsulin-like growth factor IMechano growth factorMGFOTTHUMP00000195080OTTHUMP00000195081OTTHUMP00000195082OTTHUMP00000195083OTTHUMP00000195084Somatomedin CSomatomedin-C
      see all
  • FunctionThe insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
  • Involvement in diseaseDefects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
  • Sequence similaritiesBelongs to the insulin family.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession P05019 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for IGF1 protein (Active) (ab73459)

    ab73459 has not yet been referenced specifically in any publications.

    Publishing research using ab73459 ? Please let us know so that we can cite the reference in this datasheet

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