Anti-IGF2 antibody [RM0100-3J42] (ab86485)
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
- Concentration information loading...
- Purification notesThe IgG fraction of culture supernatant was purified by protein A/G affinity chromatography and 0.2µm filtered.
- Clonality Monoclonal
- Clone numberRM0100-3J42
- Research Areas
Our Abpromise guarantee covers the use of ab86485 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Sandwich ELISA||sELISA: Use a concentration of 1 µg/ml. Can be paired for Sandwich ELISA with Rabbit polyclonal to IGF2 (ab18954). For sandwich ELISA, use this antibody as Capture at 1µg/ml with ab18954 as Detection.|
|WB||WB: 1/500 - 1/1000. Predicted molecular weight: 20 kDa.|
- FunctionThe insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
- Involvement in diseaseEpigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SIRS) [MIM:180860]. SIRS is a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations.
- Sequence similaritiesBelongs to the insulin family.
modificationsO-glycosylated with a core 1 or possibly core 8 glycan.
- Cellular localizationSecreted.
- C11orf43 antibodyIGF 2 antibodyIGF II antibody
- IGF-II antibodyIGF2 antibodyIGF2_HUMAN antibodyIGFII antibodyINSIGF antibodyinsulin like growth factor 2 (somatomedin A) antibodyInsulin like Growth Factor 2 antibodyInsulin like growth factor II antibodyInsulin like growth factor II precursor antibodyInsulin like growth factor type 2 antibodypp9974 antibodyPreptin antibodyputative insulin like growth factor II associated protein antibodySomatomedin A antibodySomatomedin-A antibody
Anti-IGF2 antibody [RM0100-3J42] images
References for Anti-IGF2 antibody [RM0100-3J42] (ab86485)
ab86485 has not yet been referenced specifically in any publications.