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Anti-IGFBP1 antibody (ab4249)

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Overview

Product name

Anti-IGFBP1 antibody
See all IGFBP1 products (7) ...

Description

Rabbit polyclonal to IGFBP1

Specificity

Recognizes human IGFBP 1. Slight crossreactivity with IGFBP 2, 3, 4 and 5.

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Human, Pig

Does not react with

Sheep, Goat, Horse, Cow

Immunogen

Full length native protein (purified) from human amniotic fluid.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Atherosclerosis >> Diabetes associated
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab4249 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IP

     

Application notes

IP: 1/500. Precipitates >90% of 10ng IGFBP 1.
WB: 1/1000. Detects 10ng SDS denatured human IGFBP 1. Predicted molecular weight: 30 kDa.
Not tested in other applications.

Optimal dilutions/concentrations should be determined by the end user.

Target

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Sequence similarities

Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.

Post-translational
modifications

Phosphorylated; probably by casein kinase II. Alters the affinity of the protein for IGFs.

Cellular localization

Secreted.

Target information above from: UniProt accessionP08833 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AFBP antibody
  • Alpha pregnancy associated endometrial globulin antibody
  • Amniotic fluid binding protein antibody
  • Binding protein 25 antibody
  • Binding protein 26 antibody
  • Binding protein 28 antibody
  • Growth hormone independent binding protein antibody
  • hIGFBP 1 antibody
  • hIGFBP1 antibody
  • IBP 1 antibody
  • IBP-1 antibody
  • IBP1 antibody
  • IBP1_HUMAN antibody
  • IGF binding protein 1 antibody
  • IGF BP25 antibody
  • IGF-binding protein 1 antibody
  • IGFBP 1 antibody
  • IGFBP-1 antibody
  • IGFBP1 antibody
  • Insulin Like Growth Factor Binding Protein 1 antibody
  • Insulin-like growth factor-binding protein 1 antibody
  • Placental protein 12 antibody
  • PP 12 antibody
  • PP12 antibody
see all

Database links

References for Anti-IGFBP1 antibody (ab4249)

ab4249 has not yet been referenced specifically in any publications.

Publishing research using ab4249? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"