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Product Name 

IGFBP2 antibody [1.A.16]

 

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Product type 

Primary antibodies

Description 

Mouse monoclonal [1.A.16] to IGFBP2

Immunogen 

Yeast derived recombinant protein (Human).

Reacts with 
(species key)

Hu

Specificity 

Recognizes human IGFBP 2 on ELISA analysis.

Tested applications 
(see key)

ELISA, WB


Abreviews 

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(see key)


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Application notes 
(see key)

Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 35 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Secreted

Research areas 

Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Cancer >> Growth factors >> Insulin and insulin-like
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like

Relevance 

IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness

 

Alternative names IGFBP2 antibody [1.A.16] (ab4243)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

3485    (Human)

Omim

    

146731    (Human)

SwissProt

    

P18065    (Human)

Unigene

    

438102    (Human)

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

1.A.16

Isotype 

IgM

Purity 

Protein G purified

Storage buffer 

0.1M Tris HCl, pH 7.5, 50% glycerol

Material safety datasheet (MSDS) for this product:
Glycerol MSDS

Form 

Liquid

Concentration 

0.050 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this IGFBP2 antibody [1.A.16] is on this datasheet. But please do contact us if you would like any reassurance!



References for IGFBP2 antibody [1.A.16] (ab4243)

Specific publication references   This product has been used in:

Walker G et al. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res 13:1438-44 (2007). PubMed: 17332286

If you publish research using ab4243 please let us know so that we can cite the reference on this datasheet.

 

Search PubMed (MEDLINE) for references to IGFBP2

 

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IGFBP2 antibody [1.A.16] - related products:

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Compatible IgM Secondary for IGFBP2 antibody [1.A.16]

ab8516

  

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ab8517

  

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ab9167

  

Goat polyclonal to Mouse IgM

ab9175

  

Rabbit polyclonal to Mouse IgM

 

Other IGFBP2 Antibodies

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