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Products:Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Overview
Product name
Anti-IGFBP2 antibody [1.A.16]
See all IGFBP2 products (7) ...
Description
Mouse monoclonal [1.A.16] to IGFBP2
Specificity
Recognizes human IGFBP 2 on ELISA analysis.
Tested applications
ELISA, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Yeast derived recombinant protein (Human).
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
0.1M Tris HCl, pH 7.5, 50% glycerol
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
1.A.16
Isotype
IgM
Research areas
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Cancer >> Growth factors >> Insulin and insulin-like
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Applications
Show applications key
Our Abpromise guarantee covers the use of ab4243 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 35 kDa.
Target
Function
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Sequence similarities
Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.
Domain
The C-terminus is required for IGF-binding and growth inhibition.
Post-translational
modifications
O-glycosylated.
Cellular localization
Secreted.
Target information above from: UniProt accessionP18065
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- BP 2 antibody
- BP2 antibody
- IBP 2 antibody
see all
Database links
- Entrez Gene: 3485 Human
- Omim: 146731 Human
- SwissProt: P18065 Human
- Unigene: 438102 Human
References for Anti-IGFBP2 antibody [1.A.16] (ab4243)
This product has been referenced in:
- Walker Get al. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res 13:1438-44 (2007).Read more (PubMed: 17332286) »
See 1 publication for this product
Publishing research using ab4243? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"