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Product Name
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IGFBP2 antibody [1.A.16]
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See all IGFBP2 antibodies (6)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [1.A.16] to IGFBP2
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Immunogen
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Yeast derived recombinant protein (Human).
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Reacts with
(species key)
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Hu
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Specificity
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Recognizes human IGFBP 2 on ELISA analysis.
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Tested applications
(see key)
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ELISA, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
ELISA: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 35 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Cancer >> Growth factors >> Insulin and insulin-like
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
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Relevance
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IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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1.A.16
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Isotype
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IgM
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Purity
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Protein G purified
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Storage buffer
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0.1M Tris HCl, pH 7.5, 50% glycerol Material safety datasheet (MSDS) for this product:
Glycerol MSDS
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Form
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Liquid
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Concentration
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0.050 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this IGFBP2 antibody [1.A.16] is on this datasheet. But please do contact us if you would like any reassurance! |
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References for IGFBP2 antibody [1.A.16] (ab4243)
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This product has been used in:
Walker G et al. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res 13:1438-44 (2007). PubMed: 17332286
If you publish research using ab4243 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to IGFBP2
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IGFBP2 antibody [1.A.16] - more information
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