You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Related products

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-IGFBP3 antibody (ab4248)

CodeSizePriceAbpointsAvailability
    
Add to basket
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-IGFBP3 antibody
See all IGFBP3 products (10) ...

Description

Rabbit polyclonal to IGFBP3

Specificity

Recognizes human IGFBP 3. Slight crossreactivity with other IGF binding proteins: IGFBP 1: ~10%, IGFBP 2: <0.2%, IGFBP 4: <0.2%, IGFBP 5: <0.2%.

Tested applications

WB, IPmore details

Cross reactivity

Reacts with

Human

Does not react with

Rat, Horse, Cow, Pig

Immunogen

Recombinant full length protein (Human IGFBP 3 expressed in CHO cells).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Cardiovascular >> Atherosclerosis >> Apoptosis
Cardiovascular >> Atherosclerosis >> Diabetes associated
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Cardiovascular >> Angiogenesis >> Angiogenic Factors
Signal Transduction >> Protein Phosphorylation >> Tyrosine Phosphatases
Cell Biology >> Apoptosis >> Receptors >> Associated Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab4248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Tissue specificity

Expressed by most tissues. Present in plasma.

Sequence similarities

Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.

Developmental stage

IGFBP3 levels are higher during extrauterine life and peak during puberty.

Domain

The thyroglobulin type-1 domain mediates interaction with HN.

Post-translational
modifications

Phosphorylation sites are present in the extracelllular medium.

Cellular localization

Secreted.

Target information above from: UniProt accessionP17936 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Acid stable subunit of the 140 K IGF complex antibody
  • Binding protein 29 antibody
  • Binding protein 53 antibody
  • BP 53 antibody
  • BP53 antibody
  • Growth hormone dependent binding protein antibody
  • IBP 3 antibody
  • IBP-3 antibody
  • IBP3 antibody
  • IBP3 antibody
  • IBP3_HUMAN antibody
  • IGF binding protein 3 antibody
  • IGF-binding protein 3 antibody
  • IGFBP 3 antibody
  • IGFBP-3 antibody
  • IGFBP3 antibody
  • Insulin Like Growth Factor Binding Protein 3 antibody
  • Insulin-like growth factor-binding protein 3 antibody
see all

Database links

References for Anti-IGFBP3 antibody (ab4248)

This product has been referenced in:

  • Walker Get al. Insulin-like growth factor binding proteins IGFBP3, IGFBP4, and IGFBP5 predict endocrine responsiveness in patients with ovarian cancer. Clin Cancer Res 13:1438-44 (2007).Read more (PubMed: 17332286) »

See 1 publication for this product

Publishing research using ab4248? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"