|
|
|
|
|
Product Name
|
IGFBP5 antibody [1.A.18]
|
| |
See all IGFBP5 antibodies (4)...
|
|
Product type
|
Primary antibodies
|
|
Description
|
Mouse monoclonal [1.A.18] to IGFBP5
|
|
Immunogen
|
Human recombinant IGF binding Protein 5 (yeast derived recombinant protein).
|
|
Reacts with
(species key)
|
Hu
|
|
Specificity
|
Strongly recognizes human IGFBP 5 on ELISA and Western blot analysis.
It is not cross reactive to other IGF binding proteins in Western blot analysis (1/100 dilution).
|
|
Tested applications
(see key)
|
ELISA, WB
|
|
|
Abreviews
|
|
|
|
Application notes
(see key)
|
Recommended dilutions
ELISA: 1/100 - 1/1000.
WB: 1/100 - 1/1000. Predicted molecular weight: 30 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
|
|
Cellular localization
|
Secreted
|
|
Research areas
|
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other
|
|
Relevance
|
IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.
|
|
|
|
|
Database links
|
The links below go to external sites and will open in a new browser window |
|
Raised in
|
Mouse
|
|
Clonality
|
Monoclonal
|
|
Clone number
|
1.A.18
|
|
Isotype
|
IgG1
|
|
Purity
|
Protein G purified
|
|
Storage buffer
|
PBS pH 7.5 0.1M Tris-HCl 40% glycerol. Material safety datasheet (MSDS) for this product:
Glycerol MSDS
|
|
Form
|
Liquid
|
|
Concentration
|
0.050 mg/ml
|
|
Storage instructions
|
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
|
| |
At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this IGFBP5 antibody [1.A.18] is on this datasheet. But please do contact us if you would like any reassurance! |
 |
|
| |
|
Search PubMed (MEDLINE) for references to IGFBP5
|
| |
IGFBP5 antibody [1.A.18] - more information
|
Customer reviews (feedback) regarding IGFBP5 antibody [1.A.18] |
Customer FAQs regarding IGFBP5 antibody [1.A.18] |
Protocols for IGFBP5 antibody [1.A.18] |
Price and availability of products related to IGFBP5 antibody [1.A.18] |
| |
IGFBP5 antibody [1.A.18] - related products:
|
|
|
| |
IGFBP5 antibody [1.A.18] - other tools:
|
Contact Abcam with a Technical Enquiry about IGFBP5 antibody [1.A.18] |
| |
All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Pricing information loading
