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Anti-IGFBP5 antibody [1.A.18] (ab4257)

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Overview

Product name

Anti-IGFBP5 antibody [1.A.18]
See all IGFBP5 products (5) ...

Description

Mouse monoclonal [1.A.18] to IGFBP5

Specificity

Strongly recognizes human IGFBP 5 on ELISA and Western blot analysis. It is not cross reactive to other IGF binding proteins in Western blot analysis (1/100 dilution).

Tested applications

ELISA, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Human recombinant IGF binding Protein 5 (yeast derived recombinant protein).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS pH 7.5 0.1M Tris-HCl 40% glycerol.

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

1.A.18

Isotype

IgG1

Research areas

Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab4257 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ELISA

     ELISA: 1/100 - 1/1000.

    ELISA: 1/100 - 1/1000.

  • ShowHide

    WB

     WB: 1/100 - 1/1000.Predi...Read more →

    WB: 1/100 - 1/1000.Predicted molecular weight: 30 kDa.

Target

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Tissue specificity

Osteosarcoma, and at lower levels in liver, kidney and brain.

Sequence similarities

Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.

Cellular localization

Secreted.

Target information above from: UniProt accessionP24593 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • IBP 5 antibody
  • IBP-5 antibody
  • IBP5 antibody
  • IBP5_HUMAN antibody
  • IGF binding protein 5 antibody
  • IGF BP5 antibody
  • IGF-binding protein 5 antibody
  • IGFBP 5 antibody
  • IGFBP-5 antibody
  • IGFBP5 antibody
  • Insulin Like Growth Factor Binding Protein 5 antibody
  • Insulin-like growth factor-binding protein 5 antibody
see all

Database links

References for Anti-IGFBP5 antibody [1.A.18] (ab4257)

This product has been referenced in:

  • Sokolovic Aet al. Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells. Fibrogenesis Tissue Repair 3:3 (2010). WB; Human.Read more (PubMed: 20163708) »
  • Tanno Bet al. Bim-dependent apoptosis follows IGFBP-5 down-regulation in neuroblastoma cells. Biochem Biophys Res Commun 351:547-52 (2006). WB; Human.Read more (PubMed: 17067554) »

See all 2 publications for this product

Publishing research using ab4257? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"