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Product Name 

IGFBP5 antibody [1.A.18]

 

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Product type 

Primary antibodies

Description 

Mouse monoclonal [1.A.18] to IGFBP5

Immunogen 

Human recombinant IGF binding Protein 5 (yeast derived recombinant protein).

Reacts with 
(species key)

Hu

Specificity 

Strongly recognizes human IGFBP 5 on ELISA and Western blot analysis.
It is not cross reactive to other IGF binding proteins in Western blot analysis (1/100 dilution).

Tested applications 
(see key)

ELISA, WB


Abreviews 

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Application notes 
(see key)

Recommended dilutions
ELISA: 1/100 - 1/1000.
WB: 1/100 - 1/1000. Predicted molecular weight: 30 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Secreted

Research areas 

Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other

Relevance 

IGFBP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFBP5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGFBP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.

 

Alternative names IGFBP5 antibody [1.A.18] (ab4257)

Database links 

The links below go to external sites and will open in a new browser window

Entrez Gene

    

3488    (Human)

GeneCard

    

GC02M217245    (Human)

Omim

    

146734    (Human)

SwissProt

    

P24593    (Human)

Unigene

    

607212    (Human)

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

1.A.18

Isotype 

IgG1

Purity 

Protein G purified

Storage buffer 

PBS pH 7.5 0.1M Tris-HCl 40% glycerol.

Material safety datasheet (MSDS) for this product:
Glycerol MSDS

Form 

Liquid

Concentration 

0.050 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

 

At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this IGFBP5 antibody [1.A.18] is on this datasheet. But please do contact us if you would like any reassurance!


 

Search PubMed (MEDLINE) for references to IGFBP5

 

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