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Products:Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other
Overview
Product name
Anti-IGFBP5 antibody [RM0097-12C23]
See all IGFBP5 products (5) ...
Description
Rat monoclonal [RM0097-12C23] to IGFBP5
Specificity
No cross reactivity seen to other mouse IGFBP proteins.
Tested applications
Cross reactivity
Reacts with
Mouse
Immunogen
Recombinant mouse IGFBP5
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
IgG fraction of culture supernatant purified by Protein A/G affinity chromatography and 0.2 µm filtered.
Primary antibody notes
ab86463 was produced from a hybridoma (mouse myeloma fused with spleen cells from an immunized rat).
Clonality
Monoclonal
Clone number
RM0097-12C23
Isotype
IgG2
Research areas
Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other
Applications
Show applications key
Our Abpromise guarantee covers the use of ab86463 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/500 - 1/1000.Predicted molecular weight: 30 kDa.
Target
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Tissue specificity
Osteosarcoma, and at lower levels in liver, kidney and brain.
Sequence similarities
Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.
Cellular localization
Secreted.
Target information above from: UniProt accessionP24593
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- IBP 5 antibody
- IBP-5 antibody
- IBP5 antibody
see all
Database links
- Entrez Gene: 16011 Mouse
- SwissProt: Q07079 Mouse
- SwissProt: Q3UQV0 Mouse
- Unigene: 405761 Mouse
References for Anti-IGFBP5 antibody [RM0097-12C23] (ab86463)
ab86463 has not yet been referenced specifically in any publications.
Publishing research using ab86463? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"