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Anti-IGFBP5 antibody (ab4255)

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Overview

Product name

Anti-IGFBP5 antibody
See all IGFBP5 products (5) ...

Description

Rabbit polyclonal to IGFBP5

Specificity

IGFBP 1 = < 0.5%, IGFBP 2 = < 0.1%, IGFBP 3 = < 0.1%, IGFBP 4 = < 0.5%.

Tested applications

WB, IP, IHC-Pmore details

Cross reactivity

Reacts with

Rat, Human

Immunogen

HPLC purified IGFBP 5 isolated from conditioned medium of transfected CHO cells.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Signal Transduction >> Growth Factors/Hormones >> Insulin / Insulin-like
Signal Transduction >> Signaling Pathway >> Lipid Signaling >> Other

Applications

Show applications key

Our Abpromise guarantee covers the use of ab4255 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • WB

     

  • IP

     

  • IHC-P

     

Application notes

IHC-P: 1/200 (from PMID 17575226)
IP: 4µl immunoprecipitates IGFBP 5 from 500µl concentrated T98G serum free culture supernatant.
WB: 1/1000. Detects IGFBP 5 in concentrated serum free T98G culture supernatant as well as fragments of 23 and 18kDa. Predicted molecular weight: 31 kDa.
Not tested in other applications.

Optimal dilutions/concentrations should be determined by the end user.

Target

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Tissue specificity

Osteosarcoma, and at lower levels in liver, kidney and brain.

Sequence similarities

Contains 1 IGFBP N-terminal domain.
Contains 1 thyroglobulin type-1 domain.

Cellular localization

Secreted.

Target information above from: UniProt accessionP24593 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • IBP 5 antibody
  • IBP-5 antibody
  • IBP5 antibody
  • IBP5_HUMAN antibody
  • IGF binding protein 5 antibody
  • IGF BP5 antibody
  • IGF-binding protein 5 antibody
  • IGFBP 5 antibody
  • IGFBP-5 antibody
  • IGFBP5 antibody
  • Insulin Like Growth Factor Binding Protein 5 antibody
  • Insulin-like growth factor-binding protein 5 antibody
see all

Database links

References for Anti-IGFBP5 antibody (ab4255)

This product has been referenced in:

  • Yoo SWet al. A Large Network of Interconnected Signaling Pathways in Human Ovarian Follicles is Supported by the Gene Expression Activity of the Granulosa Cells. Reprod Sci 18:476-84 (2011).Read more (PubMed: 21558463) »
  • Taylor KJet al. Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer. Breast Cancer Res 12:R39 (2010). IHC-P; Human.Read more (PubMed: 20569502) »

See all 5 publications for this product

Publishing research using ab4255? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"