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Overview

  • Product nameAnti-IKK alpha antibodySee all IKK alpha primary antibodies ...
  • Description
    Rabbit polyclonal to IKK alpha
  • Tested applicationsWB, IP more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    E.coli expressed recombinant fragment, corresponding to amino acids 557-745 of Human IKK alpha

Properties

Applications

Our Abpromise guarantee covers the use of ab25108 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/2000. Predicted molecular weight: 85 kDa.
IP IP: 1/500.

Target

  • FunctionActs as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
  • Tissue specificityWidely expressed.
  • Involvement in diseaseDefects in CHUK are the cause of cocoon syndrome (COCOS) [MIM:613630]; also known as fetal encasement syndrome. COCOS is a lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications    Phosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
    Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
  • Cellular localizationCytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.

    • Target information above from: UniProt accession O15111 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        chuk antibodyCHUK1 antibodyConserved Helix Loop Helix Ubiquitous Kinase antibody
        Conserved helix loop ubiquitous kinase antibodyConserved helix-loop-helix ubiquitous kinase antibodyI Kappa B Kinase 1 antibodyI Kappa B Kinase Alpha antibodyI-kappa-B kinase 1 antibodyI-kappa-B kinase alpha antibodyIkappaB kinase antibodyIkB kinase alpha subunit antibodyIKBKA antibodyIKK 1 antibodyIKK A antibodyIKK a kinase antibodyIKK-A antibodyIKK-alpha antibodyIKK1 antibodyIKK1 antibodyIKKA antibodyIKKA antibodyIKKA_HUMAN antibodyInhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibodyInhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibodyInhibitor of nuclear factor kappa-B kinase subunit alpha antibodyNFKBIKA antibodyNFKBIKA antibodyNuclear Factor Kappa B Inhibitor Kinase Alpha antibodyNuclear factor NF kappa B inhibitor kinase alpha antibodyNuclear factor NF-kappa-B inhibitor kinase alpha antibodyNuclear factor NFkappaB inhibitor kinase alpha antibodyNuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibodyTCF-16 antibodyTCF16 antibodyTCF16 antibodyTranscription factor 16 antibody
      see all

    Anti-IKK alpha antibody images

    • Western blot - IKK alpha antibody (ab25108)
      Western blot - IKK alpha antibody (ab25108)
      Anti-IKK alpha antibody (ab25108) at 1/2000 dilution + RBL cells

      Predicted band size : 85 kDa

    References for Anti-IKK alpha antibody (ab25108)

    ab25108 has not yet been referenced specifically in any publications.

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