Anti-IKK alpha antibody (ab7609)
- Product nameAnti-IKK alpha antibodySee all IKK alpha primary antibodies ...
- DescriptionRabbit polyclonal to IKK alpha
- SpecificityControl peptide (ab 7610) will compete only with the specific reaction of antiserum with the IKKa subunit.
- Tested applicationsDot Blot, ELISA, IP, WB more details
- Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide conjugated to KLH - which corresponds to the highly conserved C-terminus region of the human protein.
- EpitopeRecognition is at the highly conserved C-terminal region.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.01% Sodium Azide
- PurityWhole antiserum
- Purification notesThis product was prepared from monospecific antiserum by delipidation and defibrination.
- Clonality Polyclonal
Our Abpromise guarantee covers the use of ab7609 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: Use at an assay dependant dilution.
IP: Use at an assay dependant dilution.
WB: 1/1000. Detects a band of approximately 85 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionActs as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.
- Tissue specificityWidely expressed.
- Involvement in diseaseDefects in CHUK are the cause of cocoon syndrome (COCOS) [MIM:613630]; also known as fetal encasement syndrome. COCOS is a lethal syndrome characterized by multiple fetal malformations including defective face and seemingly absent limbs, which are bound to the trunk and encased under the skin.
- Sequence similaritiesBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Contains 1 protein kinase domain.
modificationsPhosphorylated by MAP3K14/NIK, AKT and to a lesser extent by MEKK1, and dephosphorylated by PP2A. Autophosphorylated.
Acetylation of Thr-179 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B signaling pathway.
- Cellular localizationCytoplasm. Nucleus. Shuttles between the cytoplasm and the nucleus.
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