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Anti-IL1 beta antibody [5C10] (HRP) (ab8321)

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Overview

  • Product nameAnti-IL1 beta antibody [5C10] (HRP)See all IL1 beta primary antibodies ...
  • Description
    Mouse monoclonal [5C10] to IL1 beta (HRP)
  • ConjugationHRP
  • SpecificityDoes not inhibit the biological activity of Interleukin-1.
  • Tested applicationsELISA, ICC, Sandwich ELISA more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant beta human Interleukin-1

Properties

Applications

Our Abpromise guarantee covers the use of ab8321 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA ELISA: Use at an assay dependent dilution.
ICC ICC: Use at an assay dependent dilution.
Sandwich ELISA sELISA: Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [6E10] to IL1 beta (ab8319) and Mouse monoclonal [11E5] to IL1 beta (ab8320). Can be used as Detection antibody with recommended pairs. Coating is a mixture of the recommended pairs.

Target

  • FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • Sequence similaritiesBelongs to the IL-1 family.
  • DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
  • Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

    • Target information above from: UniProt accession P01584 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Catabolin antibodyH1 antibodyHematopoietin 1 antibody
        IFN beta inducing factor antibodyIL 1 antibodyIL 1 beta antibodyIL 1B antibodyIL-1 beta antibodyIL1 BETA antibodyIL1B antibodyIL1B_HUMAN antibodyIL1F2 antibodyInterleukin 1 beta antibodyInterleukin 1 beta precursor antibodyInterleukin-1 beta antibodyLAF antibodyOAF antibodyOsteoclast activating factor antibodyOTTHUMP00000162031 antibodyPreinterleukin 1 beta antibodyPreinterleukin beta antibodyPro interleukin 1 beta antibody
      see all

    References for Anti-IL1 beta antibody [5C10] (HRP) (ab8321)

    ab8321 has not yet been referenced specifically in any publications.

    Publishing research using ab8321 ? Please let us know so that we can cite the reference in this datasheet

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    Here is the information requested.  

    I have processed your request to receive new vials of ab8319 and ab8321. Your new order numbers are****** and ******. Both antibodies re in stock and should arrive by 10.30am tomorrow morning.

    does this antibodie cross react with rat IL1beta

    This antibody has not been tested for cross-reactivity in rat, therefore we cannot guarantee results.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"