Anti-IL1 beta antibody [6E10] (ab8319)

Overview

  • Product nameAnti-IL1 beta antibody [6E10]See all IL1 beta primary antibodies ...
  • Description
    Mouse monoclonal [6E10] to IL1 beta
  • SpecificityDoes not inhibit the biological activity of Interleukin-1.
  • Tested applicationsIHC-P, ELISA, IHC-Fr, Sandwich ELISA more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant beta human Interleukin-1

Properties

Applications

Our Abpromise guarantee covers the use of ab8319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P Use at an assay dependent dilution.
ELISA Use at an assay dependent dilution.
IHC-Fr Use at an assay dependent dilution.
Sandwich ELISA Use at an assay dependent dilution. Can be paired for Sandwich ELISA with Mouse monoclonal [5C10] to IL1 beta (HRP) (ab8321). Can be used as Capture antibody with recommended pair. Coating is mixture of this antibody together with ab8320.

Target

  • FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
  • Sequence similaritiesBelongs to the IL-1 family.
  • DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
  • Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
  • Target information above from: UniProt accession P01584 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • Catabolin antibody
    • H1 antibody
    • Hematopoietin 1 antibody
    • IFN beta inducing factor antibody
    • IL 1 antibody
    • IL 1 beta antibody
    • IL 1B antibody
    • IL-1 beta antibody
    • IL1 BETA antibody
    • IL1B antibody
    • IL1B_HUMAN antibody
    • IL1F2 antibody
    • Interleukin 1 beta antibody
    • Interleukin 1 beta precursor antibody
    • Interleukin-1 beta antibody
    • LAF antibody
    • OAF antibody
    • Osteoclast activating factor antibody
    • OTTHUMP00000162031 antibody
    • Preinterleukin 1 beta antibody
    • Preinterleukin beta antibody
    • Pro interleukin 1 beta antibody
    see all

References for Anti-IL1 beta antibody [6E10] (ab8319)

ab8319 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your inquiry.
We have actually not tested ab8319 in immunohistochemistry in our own lab. We have received feedback from customers about its successful use in IHC and that is why we have added it in the possible applications list. Read More

I have processed your request to receive new vials of ab8319 and ab8321. Your new order numbers are****** and ******. Both antibodies re in stock and should arrive by 10.30am tomorrow morning.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"