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Overview

  • Product nameAnti-IL1 beta antibody [B-A15]See all IL1 beta primary antibodies ...
  • Description
    Mouse monoclonal [B-A15] to IL1 beta
  • SpecificityThis antibody is specific for both natural (pro and mature) and recombinant IL1 beta.
  • Tested applicationsBlocking, Flow Cyt more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length IL1 beta protein (Human)

Properties

Applications

Our Abpromise guarantee covers the use of ab47193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Blocking
Flow Cyt
  • Application notesBL: Use at an assay dependent dilution. Blocks IL1 beta induced proliferation on D10S murine cell line.
    FACS(intra-cytoplasmic): Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
    • Sequence similaritiesBelongs to the IL-1 family.
    • DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
    • Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

      • Target information above from: UniProt accession P01584 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          Catabolin antibodyH1 antibodyIL 1 antibody
          IL 1 beta antibodyIL-1 beta antibodyIL1 BETA antibodyIL1B antibodyIL1B_HUMAN antibodyIL1F2 antibodyInterleukin 1 beta antibodyInterleukin-1 beta antibodyOAF antibodyOTTHUMP00000162031 antibodyPreinterleukin 1 beta antibodyPro interleukin 1 beta antibody
        see all

      References for Anti-IL1 beta antibody [B-A15] (ab47193)

      ab47193 has not yet been referenced specifically in any publications.

      Publishing research using ab47193 ? Please let us know so that we can cite the reference in this datasheet

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