Anti-IL1 beta antibody [EP407Y] (ab45692)

Overview

• Product nameAnti-IL1 beta antibody [EP407Y]See all IL1 beta primary antibodies ...
• Description
  Rabbit monoclonal [EP407Y] to IL1 beta
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  

  Does not react with

  Mouse, Rat
• Immunogen

  Recombinant human IL-1 beta protein.

• General notesProduced under U.S. Patent No. 5,675,063.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• PurityTissue culture supernatant
• Clonality Monoclonal
• Clone numberEP407Y
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Obesity

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Inflammatory mediators

  • Immunology
  • Innate Immunity
  • Cytokines
  • Interleukins

Applications

Target

• FunctionProduced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
• Sequence similaritiesBelongs to the IL-1 family.
• DomainThe similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
• Cellular localizationSecreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.

Target information above from: UniProt accession P01584 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3553 Human
  • Omim: 147720 Human
  • SwissProt: P01584 Human
  • Unigene: 126256 Human

• Alternative names
  Catabolin antibodyH1 antibodyHematopoietin 1 antibody

  IFN beta inducing factor antibodyIL 1 antibodyIL 1 beta antibodyIL 1B antibodyIL-1 beta antibodyIL1 BETA antibodyIL1B antibodyIL1B_HUMAN antibodyIL1F2 antibodyInterleukin 1 beta antibodyInterleukin 1 beta precursor antibodyInterleukin-1 beta antibodyLAF antibodyOAF antibodyOsteoclast activating factor antibodyOTTHUMP00000162031 antibodyPreinterleukin 1 beta antibodyPreinterleukin beta antibodyPro interleukin 1 beta antibody

  see all

Anti-IL1 beta antibody [EP407Y] images

• 

  Western blot - IL1 beta antibody [EP407Y] (ab45692)
  Anti-IL1 beta antibody [EP407Y] (ab45692) at 1/20000 dilution + 0.05µg recombinant IL1 beta
  
  Predicted band size : 30 kDa
  Observed band size : 17 kDa (why is the actual band size different from the predicted?)