IL12 p40 protein (ab87464)
Constituents: 10% Trehalose, 1.0X PBS
Our Abpromise guarantee covers the use of ab87464 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|SDS-PAGE||SDS-PAGE: Use at an assay dependent dilution.|
- CLMF p40CLMF2Cytotoxic lymphocyte maturation factor 40 kDa subunit
- IL-12 subunit p40IL-12BIL12 subunit p40IL12BIL12B_HUMANInterleukin 12 p40Interleukin 12 subunit betaInterleukin 12BInterleukin-12 subunit betaNK cell stimulatory factor chain 2NKSFNKSF2p40
Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Genetic variations in IL12B are a cause of susceptibility to psoriasis type 11 (PSORS11) [MIM:612599]. Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
modificationsKnown to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.
References for IL12 p40 protein (ab87464)
ab87464 has not yet been referenced specifically in any publications.