You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Anti-IL15 antibody (ab7213)

CodeSizePriceAbpointsAvailability
    
Add to basket
 

  • -

  •   
  •   
  •   

  •  

  •  
  •  

  •  

  •  
Updating...

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »

Overview

Product name

Anti-IL15 antibody
See all IL15 products (15) ...

Description

Rabbit polyclonal to IL15

Tested applications

Blocking, ICC/IF, Neutralising, WBmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Recombinant full length protein (Mouse). Expressed in E. coli

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Primary antibody notes

IL-15 (14-15 kD) is a member of the four alpha-helical bundle family of cytokines. It is very similar to IL-2, except that IL-15 has an IL-15 alpha receptor subunit. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. This implies that IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases.

Clonality

Polyclonal

Isotype

IgG

Research areas

Metabolism >> Types of disease >> Obesity
Immunology >> Innate Immunity >> NK Cells
Cancer >> Tumor immunology >> Cytokines >> Interleukins
Immunology >> Immune System Diseases >> Antiviral Signaling
Immunology >> Innate Immunity >> Cytokines >> Interleukins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab7213 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Blocking

     

  • ICC/IF

     

  • Neutralising

     

  • WB

     

Application notes

BL: Use at a concentration of 10 µg/ml. (See PMID 17239632)
ICC/IF: Use at a concentration of 1 µg/ml. (See PMID 15921960)
Neut: Use at an assay dependent dilution.
WB: 1/500.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Tissue specificity

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.

Sequence similarities

Belongs to the IL-15/IL-21 family.

Cellular localization

Secreted and Cytoplasm. Nucleus. IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Target information above from: UniProt accessionP40933 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • IL 15 antibody
  • IL-15 antibody
  • IL15 antibody
  • IL15_HUMAN antibody
  • interleukin 15 antibody
  • Interleukin-15 antibody
  • Interleukin15 antibody
  • MGC9721 antibody
see all

Database links

References for Anti-IL15 antibody (ab7213)

This product has been referenced in:

  • Winau F  et al. Ito cells are liver-resident antigen-presenting cells for activating T cell responses. Immunity 26:117-29 (2007). Blocking; Human, Mouse.Read more (PubMed: 17239632) »
  • Vera M  et al. Intratumoral injection of dendritic cells transduced by an SV40-based vector expressing interleukin-15 induces curative immunity mediated by CD8+ T lymphocytes and NK cells. Mol Ther 12:950-9 (2005). ICC/IF; Mouse.Read more (PubMed: 15921960) »

See all 2 publications for this product

Publishing research using ab7213? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"