Anti-IL1RA antibody [1.384] (ab13776)
Overview
- Product nameAnti-IL1RA antibody [1.384]See all IL1RA primary antibodies ...
- DescriptionMouse monoclonal [1.384] to IL1RA
- SpecificityThis antibody recognizes both the recombinant and the natural form of human IL 1 Receptor type I.
- Tested applicationsICC/IF, ELISA, IHC-Fr more details
- Species reactivityReacts with: Human
- Immunogen
Synthetic peptide (Human).
Properties
- FormLiquid
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.02% Sodium Azide
Constituents: PBS -
Concentration information loading... - PurityProtein G purified
- Clonality Monoclonal
- Clone number1.384
- IsotypeIgG1
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab13776 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| ICC/IF | ICC/IF: Use at an assay dependent concentration. |
| ELISA | ELISA: Use at an assay dependent dilution. Can be used to measure natural human IL1 Receptor I levels in the sinovial fluid and in the serum as well as in cultured monocytes derived from patients with rheumatoid arthritis, in the range of 20 to 2000 pg/ml. See Towbin H et al. |
| IHC-Fr | IHC-Fr: Use at an assay dependent dilution. Tested on cryopreserved sections of rectal mucosal tissue from patients with shigellosis, and on frozen sections of tissue from children with tonsillitis. See references Raqib R et al. and Andersson J et al. |
Target
- FunctionInhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
- Tissue specificityThe intracellular form of IL1RN is predominantly expressed in epithelial cells.
- Involvement in diseaseGenetic variation in IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4) [MIM:612628]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
Defects in IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]; also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis (bone inflammation in multiple places), periostitis (inflammation of the membrane surrounding the bones), and pustulosis (due to skin inflammation) from birth. - Cellular localizationCytoplasm and Secreted.
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Database links
- Entrez Gene: 3557 Human
- Omim: 147679 Human
- SwissProt: P18510 Human
- Unigene: 81134 Human
Target information above from: UniProt accession
P18510
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- DIRA antibodyICIL 1RA antibodyICIL-1RA antibody
- ICIL1RA antibodyIL-1ra antibodyIL-1ra3 antibodyIL-1RN antibodyIL1 inhibitor antibodyIL1F3 antibodyIL1RA antibodyIL1RA_HUMAN antibodyIL1RN (IL1F3) antibodyIL1RN antibodyInterleukin 1 receptor antagonist antibodyInterleukin-1 receptor antagonist protein antibodyIntracellular IL 1 receptor antagonist type II antibodyIntracellular interleukin 1 receptor antagonist (icIL 1ra) antibodyIRAP antibodyMGC10430 antibodyMVCD4 antibodyType II interleukin 1 receptor antagonist antibody
see all
References for Anti-IL1RA antibody [1.384] (ab13776)
This product has been referenced in:
- Raqib R et al. Persistence of local cytokine production in shigellosis in acute and convalescent stages. Infect Immun 63:289-96 (1995). Read more (PubMed: 7806368) »
- Towbin H et al. Monoclonal antibody based enzyme-linked and chemiluminescent assays for the human interleukin-1 receptor antagonist. Application to measure hIL-1ra levels in monocyte cultures and synovial fluids. J Immunol Methods 170:125-35 (1994). Read more (PubMed: 8157985) »
