Anti-IL1RA antibody [MM0389-2V23] (ab90934)

Overview

• Product nameAnti-IL1RA antibody [MM0389-2V23]See all IL1RA primary antibodies ...
• Description
  Rat monoclonal [MM0389-2V23] to IL1RA
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant full length protein Human IL1RA.

Properties

• FormLiquid
• Storage instructionsStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
• Storage bufferPreservative: None
  Constituents: PBS
• Concentration information loading...
• PurityProtein G purified
• Purification notesThe IgG fraction of culture supernatant was purified by Protein G affinity chromatography and filtered through a 0.2 µm filter.
• Clonality Monoclonal
• Clone numberMM0389-2V23
• IsotypeIgG2
• Research Areas
  • Immunology
  • Innate Immunity
  • Cytokines
  • Interleukins

Applications

Target

• FunctionInhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
• Tissue specificityThe intracellular form of IL1RN is predominantly expressed in epithelial cells.
• Involvement in diseaseGenetic variation in IL1RN is associated with susceptibility to microvascular complications of diabetes type 4 (MVCD4) [MIM:612628]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
  Defects in IL1RN are the cause of interleukin 1 receptor antagonist deficiency (DIRA) [MIM:612852]; also known as deficiency of interleukin 1 receptor antagonist. Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T-cells. DIRA is a rare, autosomal recessive, genetic autoinflammatory disease that results in sterile multifocal osteomyelitis (bone inflammation in multiple places), periostitis (inflammation of the membrane surrounding the bones), and pustulosis (due to skin inflammation) from birth.
• Cellular localizationCytoplasm and Secreted.

Target information above from: UniProt accession P18510 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 3557 Human
  • Omim: 147679 Human
  • SwissProt: P18510 Human
  • Unigene: 81134 Human

• Alternative names
  DIRA antibodyICIL 1RA antibodyICIL-1RA antibody

  ICIL1RA antibodyIL-1ra antibodyIL-1ra3 antibodyIL-1RN antibodyIL1 inhibitor antibodyIL1F3 antibodyIL1RA antibodyIL1RA_HUMAN antibodyIL1RN (IL1F3) antibodyIL1RN antibodyInterleukin 1 receptor antagonist antibodyInterleukin-1 receptor antagonist protein antibodyIntracellular IL 1 receptor antagonist type II antibodyIntracellular interleukin 1 receptor antagonist (icIL 1ra) antibodyIRAP antibodyMGC10430 antibodyMVCD4 antibodyType II interleukin 1 receptor antagonist antibody

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