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Product name
Anti-IL21 Receptor antibody
See all IL21 Receptor products (10) ...
Description
Rabbit polyclonal to IL21 Receptor
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide: NITDQSGNYSQECGS, corresponding to amino acids 97-111 of Human IL-21 Receptor.
NITDQSGNYSQECGS
Positive control
Raji or A431 whole cell lysate.
General notes
Stable for one year.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Primary antibody notes
A novel cytokine related to IL-2 and IL-15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for IL-21 function. IL-21 and its receptor activate the JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> Cytokines >> Interleukins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab5980 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 10 µg/ml.
WB: Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 60 kDa.
Target
Relevance
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
Cellular localization
Cell Membrane; Single-pass type I membrane protein.
Alternative names
- IL 21R antibody
- IL21 Receptor antibody
- IL21R antibody
see all
Database links
- Entrez Gene: 50615 Human
- Entrez Gene: 60504 Mouse
- Entrez Gene: 308977 Rat
- Omim: 605383 Human
- SwissProt: Q9HBE5 Human
- SwissProt: Q9JHX3 Mouse
- SwissProt: Q5EBB1 Rat
- Unigene: 210546 Human
Anti-IL21 Receptor antibody images:
Western blot - IL21 Receptor antibody (ab5980)
Western blot analysis of IL-21R expression in human Raji cell lysate with ab5980 at 1 µg /ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - IL21 Receptor antibody (ab5980)
ab5980 at 10µg/ml staining IL-21R in rat lung by IHC
References for Anti-IL21 Receptor antibody (ab5980)
ab5980 has not yet been referenced specifically in any publications.
Publishing research using ab5980? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"